HaptenDB Edit

Citations: 15

z-index: 1.15

Basic information
Short name HaptenDB
Full name
Description a comprehensive database of haptens, carrierproteins and anti-hapten antibodies
URL https://webs.iiitd.edu.in/raghava/haptendb
Year founded
Last update & version
Accessibility Unaccessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Institute of Microbial Technology
Address
City
Province/State
Country/Region India
Contact name (PI/Team) Grish C. Varshney
Contact email (PI/Helpdesk) grish@imtech.res.in
Data information
Data object
Data type
Database category
Major organism
Keyword
Publications
  • HaptenDB: a comprehensive database of haptens, carrier proteins and anti-hapten antibodies. [PMID: 16443637]
    Singh MK, Srivastava S, Raghava GP, Varshney GC.

    UNLABELLED: The key requirement for successful immunochemical assay is the availability of antibodies with high specificity and desired affinity. Small molecules, when used as haptens, are not immunogenic. However, on conjugating with carrier molecule they elicit antibody response. The production of anti-hapten antibodies of desired specificity largely depends on the hapten design (preserving greatly the chemical structure and spatial conformation of target compound), selection of the appropriate carrier protein and the conjugation method. This manuscript describes a curated database HaptenDB, where information is collected from published literature and web resources. The current version of the database has 2021 entries for 1087 haptens and 25 carrier proteins, where each entry provides comprehensive details about (1) nature of the hapten, (2) 2D and 3D structures of haptens, (3) carrier proteins, (4) coupling method, (5) method of anti-hapten antibody production, (6) assay method (used for characterization) and (7) specificities of antibodies. The current version of HaptenDB covers a wide array of haptens including pesticides, herbicides, insecticides, drugs, vitamins, steroids, hormones, toxins, dyes, explosives, etc. It provides internal and external links to various databases/resources to obtain further information about the nature of haptens, carriers and respective antibodies. For structure similarity comparison of haptens, the database also integrates tools like JME Editor and JMOL for sketching, displaying and manipulating hapten 2D/3D structures online. So the database would be of great help in identifying functional group(s) in smaller molecules using antibodies as well as for the development of immunodiagnostics/therapeutics by providing data and procedures available so far for the generation of specific or cross-reactive antibodies. AVAILABILITY: HaptenDB is available on http://www.imtech.res.in/raghava/haptendb/ and http://bioinformatics.uams.edu/raghava/haptendb/ (Mirror site).

    Bioinformatics 2006:22(2)

    15 Citations (from Europe PMC, 2019-06-08)

Rank

  • Ranking in all databases: No. 2959
  • Ranking in category/categories:
    • Health and medicine: No. 556
    • Literature: No. 146
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of HaptenDB.

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Record metadata

  • Created on: 2019-05-29
    • ***ina@***c.cn [2019-05-29]

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