EGFRindb Edit

Citations: 6

z-index: 1.2

Basic information
Short name EGFRindb
Full name Epidermal Growth Factor Receptor Inhibitor Database
Description EGFRIndb is thus a comprehensive database which provides resource for the EGFR inhibitors covering both reversible and irreversible inhibitors.
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Institute of Cytology and Preventive Oncology
Country/Region India
Contact name (PI/Team) Subhash M. Agarwal
Contact email (PI/Helpdesk)
Data information
Data object
Data type
Database category
Major organism
  • EGFRIndb: epidermal growth factor receptor inhibitor database. [PMID: 24661111]
    Yadav IS, Singh H, Khan MI, Chaudhury A, Raghava GP, Agarwal SM.

    BACKGROUND: Aberrant activity of epidermal growth factor receptor (EGFR) family proteins has been found to be associated with a number of human cancers including that of lung and breast. Consequently, the search for EGFR family inhibitors, a well established target of pharmacological and therapeutic value has been ongoing. Therefore, over the years several small molecules, which compete for ATP in the kinase domain have been synthesised and some of them have proved to be effective in attenuating EGFR mediated proliferation. Thus, there exists in literature a vast amount of experimental data on EGFR tyrosine kinase inhibitors. In this paper, we describe a comprehensive database EGFRIndb that contains details of the small molecular inhibitors of EGFR family. DESCRIPTION: EGFRIndb is a literature curated database of small synthetic molecular inhibitors of EGFR. It consists of 4581 compounds showing in vitro inhibitory activities (IC50, IC80, GI50, GI90, EC50, Ki, Kd and percentage inhibition) either against EGFR or its different isoforms i.e. Erbb2 (v-erb-b2 avian erythroblastic leukaemia viral oncogene homolog 2) and Erbb4 (v-erb-b2 avian erythroblastic leukaemia viral oncogene homolog 4) or various mutants. For each compound, database provides information on structure, experimentally determined inhibitory activity of compound against kinase as well as various cell lines, properties (physical, elemental and topological) and drug likeness. Additionally, it provides information on irreversible as well as dual inhibitors that have gained importance in recent years due to the emergence of clinical resistance to known drugs. As compound activity against similar kinases is a measure of its selectivity and specificity, the database also provides this information. It also provides simple search, advanced search, browse facility as well as a tool for structure based searching. CONCLUSION: EGFRIndb gathers biological and chemical information on EGFR inhibitors from the literature. It is hoped that it will serve as a useful resource in drug discovery and provide data for docking, virtual screening and Quantitative structure-activity relationship (QSAR) model development to the cancer researchers.

    Anticancer Agents Med Chem 2014:14(7)

    6 Citations (from Europe PMC, 2019-07-27)


  • Ranking in all databases: No. 2928
  • Ranking in category/categories:
    • Interaction: No. 440
    • Health and medicine: No. 553
    • Literature: No. 149
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of EGFRindb.

Word cloud

Related Database



Record metadata

  • Created on: 2019-05-29
    • ***ina@*** [2019-05-29]

Community reviews 0 stars (0 reviews)

quality & quantity
organization & presentation
accessibility & reliability
Reviewed by