EbolaVCR Edit

Citations: 4

z-index: 1.33

Basic information
Short name EbolaVCR
Full name Ebola Virus Computational Resources
Description EbolaVCR is the in silico resources developed to facilitate scientific community fighting against deadly virus EBOLA. This server enlists possible vaccine candidates, therapeutic siRNAs and other related resources.
URL https://webs.iiitd.edu.in/oscadd/ebola
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Indraprastha Institute of Information Technology
Address
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Province/State
Country/Region India
Contact name (PI/Team) Gajendra P. S. Raghava
Contact email (PI/Helpdesk) raghava@iiitd.ac.in
Data information
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Keyword
Publications
  • A web-based resource for designing therapeutics against Ebola Virus. [PMID: 27113850]
    Dhanda SK, Chaudhary K, Gupta S, Brahmachari SK, Raghava GP.

    In this study, we describe a web-based resource, developed for assisting the scientific community in designing an effective therapeutics against the Ebola virus. Firstly, we predicted and identified experimentally validated epitopes in each of the antigens/proteins of the five known ebolaviruses. Secondly, we generated all the possible overlapping 9mer peptides from the proteins of ebolaviruses. Thirdly, conserved peptides across all the five ebolaviruses (four human pathogenic species) with no identical sequence in the human proteome, based on 1000 Genomes project, were identified. Finally, we identified peptide or epitope-based vaccine candidates that could activate both the B- and T-cell arms of the immune system. In addition, we also identified efficacious siRNAs against the mRNA transcriptome (absent in human transcriptome) of all the five ebolaviruses. It was observed that three species can potentially be targeted by a single siRNA (19mer) and 75 siRNAs can potentially target at least two species. A web server, EbolaVCR, has been developed that incorporates all the above information and useful computational tools (http://crdd.osdd.net/oscadd/ebola/).

    Sci Rep 2016:6()

    4 Citations (from Europe PMC, 2019-06-08)

Rank

  • Ranking in all databases: No. 2822
  • Ranking in category/categories:
    • Health and medicine: No. 520
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of EbolaVCR.

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Record metadata

  • Created on: 2019-05-29
    • ***ina@***c.cn [2019-05-29]

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