SARS CoV Edit

Citations: 517

z-index: 32.31

Basic information
Short name SARS CoV
Full name SARS coronavirus
Description A summary of data for the SARS coronavirus (CoV), including links to the most recent sequence data and publications, links to other SARS related resources, and a pre-computed alignment of genome sequences from various isolates.
URL https://www.ncbi.nlm.nih.gov/genomes/SARS/SARS.html
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution National Center for Biotechnology Information
Address 8600 Rockville Pike, Bethesda MD, 20894 USA
City Bethesda
Province/State
Country/Region United States
Contact name (PI/Team) SARS CoV team
Contact email (PI/Helpdesk) genomes@ncbi.nlm.nih.gov
Data information
Data object
Data type
Database category
Major organism
Keyword
Publications
  • Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. [PMID: 12927536]
    Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL, Guan Y, Rozanov M, Spaan WJ, Gorbalenya AE.

    The genome organization and expression strategy of the newly identified severe acute respiratory syndrome coronavirus (SARS-CoV) were predicted using recently published genome sequences. Fourteen putative open reading frames were identified, 12 of which were predicted to be expressed from a nested set of eight subgenomic mRNAs. The synthesis of these mRNAs in SARS-CoV-infected cells was confirmed experimentally. The 4382- and 7073 amino acid residue SARS-CoV replicase polyproteins are predicted to be cleaved into 16 subunits by two viral proteinases (bringing the total number of SARS-CoV proteins to 28). A phylogenetic analysis of the replicase gene, using a distantly related torovirus as an outgroup, demonstrated that, despite a number of unique features, SARS-CoV is most closely related to group 2 coronaviruses. Distant homologs of cellular RNA processing enzymes were identified in group 2 coronaviruses, with four of them being conserved in SARS-CoV. These newly recognized viral enzymes place the mechanism of coronavirus RNA synthesis in a completely new perspective. Furthermore, together with previously described viral enzymes, they will be important targets for the design of antiviral strategies aimed at controlling the further spread of SARS-CoV.

    J Mol Biol 2003:331(5)

    517 Citations (from Europe PMC, 2019-07-13)

Rank

  • Ranking in all databases: No. 219
  • Ranking in category/categories:
    • Gene genome and annotation: No. 86
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of SARS CoV.

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Cited

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Record metadata

  • Created on: 2019-04-22
    • ***ina@***c.cn [2019-04-22]
    • ***ina@***c.cn [2019-04-22]

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