Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

SARS CoV (SARS coronavirus)

General information

Description: A summary of data for the SARS coronavirus (CoV), including links to the most recent sequence data and publications, links to other SARS related resources, and a pre-computed alignment of genome sequences from various isolates.
Year founded: 2003
Last update:
Version:
Accessibility:
Manual:
Accessible
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Country/Region: United States
Data type:
DNA
Data object:
Database category:
Major organism:
Keywords:

Contact information

University/Institution: National Center for Biotechnology Information
Address: 8600 Rockville Pike, Bethesda MD, 20894 USA
City: Bethesda
Province/State:
Country/Region: United States
Contact name (PI/Team): SARS CoV team
Contact email (PI/Helpdesk): genomes@ncbi.nlm.nih.gov

Related Database

Record metadata

Created on: 2019-04-22
Curated by:
Lina Ma [2019-04-22]

Ranking

All databases:
230/4692 (95.119%)
Gene genome and annotation:
90/1246 (92.857%)
230
Total Rank
607
Citations
35.706
z-index

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Publications

12927536
Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. [PMID: 12927536]
Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL, Guan Y, Rozanov M, Spaan WJ, Gorbalenya AE.

The genome organization and expression strategy of the newly identified severe acute respiratory syndrome coronavirus (SARS-CoV) were predicted using recently published genome sequences. Fourteen putative open reading frames were identified, 12 of which were predicted to be expressed from a nested set of eight subgenomic mRNAs. The synthesis of these mRNAs in SARS-CoV-infected cells was confirmed experimentally. The 4382- and 7073 amino acid residue SARS-CoV replicase polyproteins are predicted to be cleaved into 16 subunits by two viral proteinases (bringing the total number of SARS-CoV proteins to 28). A phylogenetic analysis of the replicase gene, using a distantly related torovirus as an outgroup, demonstrated that, despite a number of unique features, SARS-CoV is most closely related to group 2 coronaviruses. Distant homologs of cellular RNA processing enzymes were identified in group 2 coronaviruses, with four of them being conserved in SARS-CoV. These newly recognized viral enzymes place the mechanism of coronavirus RNA synthesis in a completely new perspective. Furthermore, together with previously described viral enzymes, they will be important targets for the design of antiviral strategies aimed at controlling the further spread of SARS-CoV.

J Mol Biol. 2003:331(5) | 607 Citations (from Europe PMC, 2020-09-12)