| URL: | http://circatlas.biols.ac.cn |
| Full name: | An integrated resource of circRNAs in vertebrates |
| Description: | circAtlas 2.0 integrates millions of circRNAs across 7 species (human, macaca, mouse, rat, pig, chicken, dog) and a variety of tissues. The circAtlas 2.0 can fill this gap by integrating the most comprehensive circRNAs and their expression and functional profiles in vertebrates, which provides a foundation for circRNA studies and serves as a powerful starting point to investigate their biological significance. |
| Year founded: | 2020 |
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| Version: | v2.0 |
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| Country/Region: | China |
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| University/Institution: | Beijing Institutes of Life Science, Chinese Academy of Sciences |
| Address: | |
| City: | Beijing |
| Province/State: | Beijing |
| Country/Region: | China |
| Contact name (PI/Team): | Fangqing Zhao |
| Contact email (PI/Helpdesk): | zhfq@biols.ac.cn |
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CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes. [PMID: 32345360]
Existing circular RNA (circRNA) databases have become essential for transcriptomics. However, most are unsuitable for mining in-depth information for candidate circRNA prioritization. To address this, we integrate circular transcript collections to develop the circAtlas database based on 1070 RNA-seq samples collected from 19 normal tissues across six vertebrate species. This database contains 1,007,087 highly reliable circRNAs, of which over 81.3% have been assembled into full-length sequences. We profile their expression pattern, conservation, and functional annotation. We describe a novel multiple conservation score, co-expression, and regulatory networks for circRNA annotation and prioritization. CircAtlas can be accessed at http://circatlas.biols.ac.cn/. |