| URL: | http://bioinfo.imtech.res.in/manojk/sarna |
| Full name: | Resource of Small Activating RNAs for Up-regulating the Gene Expression |
| Description: | RNA activation (RNAa) is the phenomena resposible for RNA based gene activation involving small RNA molecules known as Small activating RNAs (saRNAs) targeted against the promoter. saRNAdb is the first attempt to integrate information of experimentally verified saRNAs, proteins involved in the process and their interacting proteins. |
| Year founded: | 2018 |
| Last update: | |
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| Accessibility: | |
| Country/Region: | India |
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| Major species: |
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| University/Institution: | Institute of Microbial Technology |
| Address: | Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research, Sector 39A, Chandigarh 160036, India. |
| City: | Chandigarh |
| Province/State: | |
| Country/Region: | India |
| Contact name (PI/Team): | Manoj Kumar |
| Contact email (PI/Helpdesk): | manojk@imtech.res.in |
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saRNAdb: Resource of Small Activating RNAs for Up-regulating the Gene Expression. [PMID: 29625201]
RNA activation (RNAa) is the process of enhancing selective gene expression at transcriptional level using double-stranded RNAs, targeting gene promoter. These RNA molecules are usually 21 nucleotides long and termed as small activating RNAs (saRNAs). They are involved in gene regulation, epigenetics, gain-of-function studies and have potential therapeutic applications for various diseases especially cancer. RNAa is opposite to RNA interference in functionality; however, both processes share some protein machinery. There are many RNA interference centered online resources but no one for saRNAs; therefore, we developed "saRNAdb" database (http://bioinfo.imtech.res.in/manojk/sarna/). It contains 2150 manually curated saRNA entries with detailed information about their nucleotide sequences, activities, corresponding target gene, promoter and other experimental data. Besides, saRNA-promoter binding location, predicted saRNA features, tools (off-target, map) and RNAa-related proteins with their interacting partners are provided. saRNAdb is expected to assist in RNA research especially for nucleic acid-based therapeutics development. |