saRNAdb Edit

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Basic information
Short name saRNAdb
Full name Resource of Small Activating RNAs for Up-regulating the Gene Expression
Description the first attempt to integrate information of experimentally verified saRNAs, proteins involved in the process and their interacting proteins.
URL http://bioinfo.imtech.res.in/manojk/sarna
Year founded
Last update & version
Availability Free to academic users only
Contact information
University/Institution hosted Institute of Microbial Technology
Address Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research, Sector 39A, Chandigarh 160036, India.
City Chandigarh
Province/State
Country/Region India
Contact name Manoj Kumar
Contact email manojk@imtech.res.in
Data information
Data object
  • NA
Data type
  • DNA
  • RNA
  • Protein
Database category
  • Gene genome and annotation
  • Interaction
Major organism
  • NA
Keyword
  • saRNAs
  • small activating RNA
Publications
  • saRNAdb: Resource of Small Activating RNAs for Up-regulating the Gene Expression. [PMID: 29625201]
    Showkat Ahmad Dar, Manoj Kumar

    RNA activation (RNAa) is the process of enhancing selective gene expression at transcriptional level using double-stranded RNAs, targeting gene promoter. These RNA molecules are usually 21 nucleotides long and termed as small activating RNAs (saRNAs). They are involved in gene regulation, epigenetics, gain-of-function studies and have potential therapeutic applications for various diseases especially cancer. RNAa is opposite to RNA interference in functionality; however, both processes share some protein machinery. There are many RNA interference centered online resources but no one for saRNAs; therefore, we developed "saRNAdb" database (http://bioinfo.imtech.res.in/manojk/sarna/). It contains 2150 manually curated saRNA entries with detailed information about their nucleotide sequences, activities, corresponding target gene, promoter and other experimental data. Besides, saRNA-promoter binding location, predicted saRNA features, tools (off-target, map) and RNAa-related proteins with their interacting partners are provided. saRNAdb is expected to assist in RNA research especially for nucleic acid-based therapeutics development.

    J. Mol. Biol. 2018:430(15)

    0 Citations (from Europe PMC, 2019-01-19)

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Record metadata

  • Created on: 2019-01-04
    • ***d@***c.cn [2019-01-12]
    • ***d@***c.cn [2019-01-12]
    • ***d@***c.cn [2019-01-04]

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