saRNAdb Edit

Citations: 0

z-index: 0

Basic information
Short name saRNAdb
Full name Resource of Small Activating RNAs for Up-regulating the Gene Expression
Description RNA activation (RNAa) is the phenomena resposible for RNA based gene activation involving small RNA molecules known as Small activating RNAs (saRNAs) targeted against the promoter. saRNAdb is the first attempt to integrate information of experimentally verified saRNAs, proteins involved in the process and their interacting proteins.
URL http://bioinfo.imtech.res.in/manojk/sarna
Year founded
Last update & version
Availability Free to academic users only
Contact information
University/Institution hosted Institute of Microbial Technology
Address Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research, Sector 39A, Chandigarh 160036, India.
City Chandigarh
Province/State
Country/Region India
Contact name Manoj Kumar
Contact email manojk@imtech.res.in
Data information
Data object
  • NA
Data type
  • DNA
  • RNA
  • Protein
Database category
  • Gene genome and annotation
  • Interaction
  • Expression
Major organism
  • NA
Keyword
  • saRNAs
  • small activating RNA
Publications
  • saRNAdb: Resource of Small Activating RNAs for Up-regulating the Gene Expression. [PMID: 29625201]
    Showkat Ahmad Dar, Manoj Kumar

    RNA activation (RNAa) is the process of enhancing selective gene expression at transcriptional level using double-stranded RNAs, targeting gene promoter. These RNA molecules are usually 21 nucleotides long and termed as small activating RNAs (saRNAs). They are involved in gene regulation, epigenetics, gain-of-function studies and have potential therapeutic applications for various diseases especially cancer. RNAa is opposite to RNA interference in functionality; however, both processes share some protein machinery. There are many RNA interference centered online resources but no one for saRNAs; therefore, we developed "saRNAdb" database (http://bioinfo.imtech.res.in/manojk/sarna/). It contains 2150 manually curated saRNA entries with detailed information about their nucleotide sequences, activities, corresponding target gene, promoter and other experimental data. Besides, saRNA-promoter binding location, predicted saRNA features, tools (off-target, map) and RNAa-related proteins with their interacting partners are provided. saRNAdb is expected to assist in RNA research especially for nucleic acid-based therapeutics development.

    J. Mol. Biol. 2018:430(15)

    0 Citations (from Europe PMC, 2019-03-22)

Rank

  • All: 0
  • Category:
    • Gene genome and annotation: 0
    • Interaction: 0
    • Expression: 0

Related Database

No valid data.

Word cloud

Tags

Record metadata

  • Created on: 2019-01-04
    • ***ina@***c.cn [2019-01-23]
    • ***d@***c.cn [2019-01-12]
    • ***d@***c.cn [2019-01-12]
    • ***d@***c.cn [2019-01-04]

Community reviews 0 stars (0 reviews)

Data
quality & quantity
Content
organization & presentation
System
accessibility & reliability
Reviewed by