DMSeq Edit

Citations: 0

z-index: 0

Basic information
Short name DMSeq
Full name Deep Sequencing Data Repository
Description a web resource at http://DMseq.org that hosts raw and processed transcriptome data and provides a lightweight, responsive interface that enables browsing of processed data across the genome
URL http://DMseq.org
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution University of Florida
Address
City
Province/State
Country/Region United States
Contact name (PI/Team) Eric T Wang
Contact email (PI/Helpdesk) eric.t.wang@ufl.edu
Data information
Data object
Data type
Database category
Major organism
Keyword
Publications
  • Transcriptome alterations in myotonic dystrophy skeletal muscle and heart. [PMID: 30561649]
    Eric T Wang, Daniel Treacy, Katy Eichinger, Adam Struck, Joseph Estabrook, Hailey Olafson, Thomas T Wang, Kirti Bhatt, Tony Westbrook, Sam Sedehizadeh, Amanda Ward, John Day, David Brook, J Andrew Berglund, Thomas Cooper, David Housman, Charles Thornton, Christopher Burge

    Myotonic dystrophy (dystrophia myotonica, DM) is a multi-systemic disease caused by expanded CTG or CCTG microsatellite repeats. Characterized by symptoms in muscle, heart, and central nervous system, among others, it is one of the most variable diseases known. A major pathogenic event in DM is the sequestration of Muscleblind-like proteins by CUG or CCUG repeat-containing RNAs transcribed from expanded repeats, and differences in the extent of MBNL sequestration dependent on repeat length and expression level may account for some portion of the variability. However, many other cellular pathways are reported to be perturbed in DM, and the severity of specific disease symptoms varies among individuals. To help understand this variability and facilitate research into DM, we generated 120 RNASeq transcriptomes from skeletal and heart muscle derived from healthy and DM1 biopsies and autopsies. A limited number of DM2 and Duchenne Muscular Dystrophy samples were also sequenced. We analyzed splicing and gene expression, identified tissue-specific changes in RNA processing, and uncovered transcriptome changes strongly correlating with muscle strength. We created a web resource at http://DMseq.org that hosts raw and processed transcriptome data and provides a lightweight, responsive interface that enables browsing of processed data across the genome.

    Hum Mol Genet 2018:()

    0 Citations (from Europe PMC, 2019-06-08)

Rank

  • Ranking in all databases: No. 0
  • Ranking in category/categories:
    • Raw bio-data: No. 0
    • Expression: No. 0
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of DMSeq.

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Record metadata

  • Created on: 2019-01-04
    • ***ina@***c.cn [2019-01-23]
    • ***d@***c.cn [2019-01-12]
    • ***d@***c.cn [2019-01-12]
    • ***d@***c.cn [2019-01-04]

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