iEKPD Edit

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Basic information
Short name iEKPD
Full name (integrated annotations for Eukaryotic protein Kinases, protein Phosphatases & phosphoprotein-binding Domains
Description iEKPD contained 197,348 phosphorylation regulators, including 109,912 protein kinases, 23,294 protein phosphatases and 68,748 PPBD-containing proteins in 164 eukaryotic species.
Year founded
Last update & version 2018-06-10 v2.0
Availability Free to academic users only
Contact information
University/Institution hosted Huazhong University of Science and Technology
City Wuhan
Province/State Hubei
Country/Region China
Contact name Yu Xue
Contact email
Data information
Data object
  • Animal
  • Plant
  • Fungi
Data type
  • DNA
  • RNA
  • Protein
Database category
  • Genotype phenotype and variation
  • Structure
  • Health and medicine
Major organism
  • NA
  • cancer mutations
  • eukaryotic protein kinases
  • protein phosphatases
  • phosphoprotein-binding domains
  • iEKPD 2.0: an update with rich annotations for eukaryotic protein kinases, protein phosphatases and proteins containing phosphoprotein-binding domains. [PMID: 30380109]
    Yaping Guo, Di Peng, Jiaqi Zhou, Shaofeng Lin, Chenwei Wang, Wanshan Ning, Haodong Xu, Wankun Deng, Yu Xue

    Here, we described the updated database iEKPD 2.0 ( for eukaryotic protein kinases (PKs), protein phosphatases (PPs) and proteins containing phosphoprotein-binding domains (PPBDs), which are key molecules responsible for phosphorylation-dependent signalling networks and participate in the regulation of almost all biological processes and pathways. In total, iEKPD 2.0 contained 197 348 phosphorylation regulators, including 109 912 PKs, 23 294 PPs and 68 748 PPBD-containing proteins in 164 eukaryotic species. In particular, we provided rich annotations for the regulators of eight model organisms, especially humans, by compiling and integrating the knowledge from 100 widely used public databases that cover 13 aspects, including cancer mutations, genetic variations, disease-associated information, mRNA expression, DNA & RNA elements, DNA methylation, molecular interactions, drug-target relations, protein 3D structures, post-translational modifications, protein expressions/proteomics, subcellular localizations and protein functional annotations. Compared with our previously developed EKPD 1.0 (?0.5 GB), iEKPD 2.0 contains ?99.8 GB of data with an ?200-fold increase in data volume. We anticipate that iEKPD 2.0 represents a more useful resource for further study of phosphorylation regulators.

    Nucleic Acids Res. 2019:47(D1)

    0 Citations (from Europe PMC, 2019-03-22)


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  • Category:
    • Genotype phenotype and variation: 0
    • Structure: 0
    • Health and medicine: 0

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Record metadata

  • Created on: 2019-01-04
    • ***d@*** [2019-01-11]
    • ***d@*** [2019-01-11]
    • ***d@*** [2019-01-04]

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