iEKPD Edit

Citations: 0

z-index: 0

Basic information
Short name iEKPD
Full name (integrated annotations for Eukaryotic protein Kinases, protein Phosphatases & phosphoprotein-binding Domains
Description iEKPD contained 197,348 phosphorylation regulators, including 109,912 protein kinases, 23,294 protein phosphatases and 68,748 PPBD-containing proteins in 164 eukaryotic species.
URL http://iekpd.biocuckoo.org
Year founded
Last update & version 2018-06-10 v2.0
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Huazhong University of Science and Technology
Address
City Wuhan
Province/State Hubei
Country/Region China
Contact name (PI/Team) Yu Xue
Contact email (PI/Helpdesk) xueyu@mail.hust.edu.cn
Data information
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Publications
  • iEKPD 2.0: an update with rich annotations for eukaryotic protein kinases, protein phosphatases and proteins containing phosphoprotein-binding domains. [PMID: 30380109]
    Yaping Guo, Di Peng, Jiaqi Zhou, Shaofeng Lin, Chenwei Wang, Wanshan Ning, Haodong Xu, Wankun Deng, Yu Xue

    Here, we described the updated database iEKPD 2.0 (http://iekpd.biocuckoo.org) for eukaryotic protein kinases (PKs), protein phosphatases (PPs) and proteins containing phosphoprotein-binding domains (PPBDs), which are key molecules responsible for phosphorylation-dependent signalling networks and participate in the regulation of almost all biological processes and pathways. In total, iEKPD 2.0 contained 197 348 phosphorylation regulators, including 109 912 PKs, 23 294 PPs and 68 748 PPBD-containing proteins in 164 eukaryotic species. In particular, we provided rich annotations for the regulators of eight model organisms, especially humans, by compiling and integrating the knowledge from 100 widely used public databases that cover 13 aspects, including cancer mutations, genetic variations, disease-associated information, mRNA expression, DNA & RNA elements, DNA methylation, molecular interactions, drug-target relations, protein 3D structures, post-translational modifications, protein expressions/proteomics, subcellular localizations and protein functional annotations. Compared with our previously developed EKPD 1.0 (?0.5 GB), iEKPD 2.0 contains ?99.8 GB of data with an ?200-fold increase in data volume. We anticipate that iEKPD 2.0 represents a more useful resource for further study of phosphorylation regulators.

    Nucleic Acids Res 2019:47(D1)

    0 Citations (from Europe PMC, 2019-06-08)

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    • Genotype phenotype and variation: No. 0
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    • Health and medicine: No. 0
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of iEKPD.

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Record metadata

  • Created on: 2019-01-04
    • ***d@***c.cn [2019-01-11]
    • ***d@***c.cn [2019-01-11]
    • ***d@***c.cn [2019-01-04]

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