FlyXCDB Edit

Citations: 0

z-index: 0

Basic information
Short name FlyXCDB
Full name Drosophila melanogaster extracellular domain database
Description a database that contains extracellular (XC) domain information for protein-coding genes of Drosophila melanogaster (Dmel) from FlyBase (version FB2015_03).
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution University of Texas Southwestern Medical Center
Address Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
City Dallas
Country/Region United States
Contact name (PI/Team) Jimin Pei
Contact email (PI/Helpdesk)
Data information
Data object
Data type
Database category
Major organism
  • FlyXCDB-A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains. [PMID: 29890119]
    Jimin Pei, Lisa N Kinch, Nick V Grishin

    Genomes of metazoan organisms possess a large number of genes encoding cell surface and secreted (CSS) proteins that carry out crucial functions in cell adhesion and communication, signal transduction, extracellular matrix establishment, nutrient digestion and uptake, immunity, and developmental processes. We developed the FlyXCDB database ( that provides a comprehensive resource to investigate extracellular (XC) domains in CSS proteins of Drosophila melanogaster, the most studied insect model organism in various aspects of animal biology. More than 300 Drosophila XC domains were discovered in Drosophila CSS proteins encoded by over 2500 genes through analyses of computational predictions of signal peptide, transmembrane (TM) segment, and GPI-anchor signal sequence, profile-based sequence similarity searches, gene ontology, and literature. These domains were classified into six classes mainly based on their molecular functions, including protein-protein interactions (class P), signaling molecules (class S), binding of non-protein molecules or groups (class B), enzyme homologs (class E), enzyme regulation and inhibition (class R), and unknown molecular function (class U). Main cellular functions such as cell adhesion, cell signaling, and extracellular matrix composition were described for the most abundant domains in each functional class. We assigned cell membrane topology categories (E, secreted; S, type I/III single-pass TM; T, type II single-pass TM; M, multi-pass TM; and G, GPI-anchored) to the products of genes with XC domains and investigated their regulation by mechanisms such as alternative splicing and stop codon readthrough.

    J Mol Biol 2018:430(18 Pt B)

    0 Citations (from Europe PMC, 2019-07-27)


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Record metadata

  • Created on: 2019-01-04
    • ***d@*** [2019-01-11]
    • ***d@*** [2019-01-11]
    • ***d@*** [2019-01-04]

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