Citations: 1

z-index: 1

Basic information
Short name DSMNC
Full name Somatic SNVs occurring in single cells from various human and mouse
Description DSMNC is a database which provides most comprehensive catalogue of somatic SNVs occurring in single cells from various human and mouse normal tissues.
URL http://dsmnc.big.ac.cn
Year founded 2018
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Beijing Institute of Genomics, Chinese Academy of Sciences
City Beijing
Province/State Beijing
Country/Region China
Contact name (PI/Team) Jun Cai
Contact email (PI/Helpdesk) juncai@big.ac.cn
Data information
Data object
Data type
Database category
Major organism
  • DSMNC: a database of somatic mutations in normal cells. [PMID: 30380071]
    Xuexia Miao, Xi Li, Lifei Wang, Caihong Zheng, Jun Cai

    Numerous non-inherited somatic mutations, distinct from those of germ-line origin, occur in somatic cells during DNA replication per cell-division. The somatic mutations, recording the unique genetic cell-lineage 'history' of each proliferating normal cell, are important but remain to be investigated because of their ultra-low frequency hidden in the genetic background of heterogeneous cells. Luckily, the recent development of single-cell genomics biotechnologies enables the screening and collection of the somatic mutations, especial single nucleotide variations (SNVs), occurring in normal cells. Here, we established DSMNC: a database of somatic mutations in normal cells (http://dsmnc.big.ac.cn/), which provides most comprehensive catalogue of somatic SNVs in single cells from various normal tissues. In the current version, the database collected ?0.8 million SNVs accumulated in ?600 single normal cells (579 human cells and 39 mouse cells). The database interface supports the user-friendly capability of browsing and searching the SNVs and their annotation information. DSMNC, which serves as a timely and valuable collection of somatic mutations in individual normal cells, has made it possible to analyze the burdens and signatures of somatic mutations in various types of heterogeneous normal cells. Therefore, DSMNC will significantly improve our understanding of the characteristics of somatic mutations in normal cells.

    Nucleic Acids Res 2019:47(D1)

    1 Citations (from Europe PMC, 2019-07-27)


  • Ranking in all databases: No. 3203
  • Ranking in category/categories:
    • Genotype phenotype and variation: No. 411
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of DSMNC.

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Record metadata

  • Created on: 2019-01-03
    • ***d@***c.cn [2019-09-09]
    • ***d@***c.cn [2019-01-10]
    • ***d@***c.cn [2019-01-10]
    • ***d@***c.cn [2019-01-10]
    • ***d@***c.cn [2019-01-03]

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