DES-ncRNA Edit

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Basic information
Short name DES-ncRNA
Full name Knowledge Exploration System for Human miRNA and lncRNA
Description DES-ncRNA is a knowledgebase that contains information obtained through the text- and data-mining of available scientific literature and several other resources. DES-ncRNA enables exploration of associations between biological terms or keywords from literature related to human miRNA and lncRNA.
URL http://www.cbrc.kaust.edu.sa/des_ncrna/
Year founded 2017
Last update & version
Availability Free to all users
Contact information
University/Institution hosted King Abdullah University of Science and Technology
Address Computational Bioscience Research Centre Building 3, Office 4219 4700 King Abdullah University of Science and Technology Thuwal 23955-6900 Kingdom of Saudi Arabia
City Jeddah
Province/State Makkah
Country/Region Saudi Arabia
Contact name Vladimir Bajic
Contact email vladimir.bajic@kaust.edu.sa
Data information
Object(s)
  • Animal
Data type(s)
  • RNA
Data Category/Categories
  • Literature
Major organism(s)
  • Homo sapiens
Keyword(s)
  • human miRNA
  • human lncRNA
Publications
  • DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining.[PMID: 28387604]
    Adil Salhi, Magbubah Essack, Tanvir Alam, Vladan P Bajic, Lina Ma, Aleksandar Radovanovic, Benoit Marchand, Sebastian Schmeier, Zhang Zhang, Vladimir B Bajic

    Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA ( www.cbrc.kaust.edu.sa/des_ncrna ). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource.

    RNA Biol 2017:14(7)

    0 Citations (from Europe PMC, 2018-10-05)

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  • Created on: 2018-05-13
    • Zou Dong [2018-05-14]
    • Ma Lina [2018-05-14]
    • zhao li [2018-05-13]

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