Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

Gp53MD (germline p53 mutations database )

General information

Description: The germline p53 mutations database lists 580 tumours in 448 individuals belonging to 122 independent pedigrees.
Year founded: 1998
Last update:
Version:
Accessibility:
Manual:
Unaccessible
Real time : Checking...
Country/Region: Czech Republic
Data type:
DNA
Data object:
Database category:
Major organism:
Keywords:

Contact information

University/Institution: Charles University
Address:
City:
Province/State:
Country/Region: Czech Republic
Contact name (PI/Team): P. Goetz
Contact email (PI/Helpdesk): petr.goetz@lfmotol.cuni.cz

Record metadata

Created on: 2018-02-09
Curated by:
zhang yang [2018-02-24]
pei wang [2018-02-09]

Ranking

All databases:
3420/4549 (24.841%)
Genotype phenotype and variation:
460/611 (24.877%)
Health and medicine:
662/917 (27.917%)
3420
Total Rank
19
Citations
0.864
z-index

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Publications

9399838
A database of germline p53 mutations in cancer-prone families. [PMID: 9399838]
Sedlacek Z, Kodet R, Poustka A, Goetz P.

We created a comprehensive database covering all published cases of germline p53 mutations. The current version lists 580 tumours in 448 individuals belonging to 122 independent pedigrees. The database describes each p53 mutation (type of the mutation, exon and codon affected by the mutation, nucleotide and amino acid change), each family (family history of cancer, diagnosis of Li-Fraumeni syndrome), each affected individual (sex, generation, p53 status, from which parent the mutation was inherited) and each tumour (type, age of onset, p53 status-loss of heterozygosity, immunostaining). Each entry contains the original reference(s). The database is freely available and can be obtained from http://www.lf2.cuni.cz

Nucleic Acids Res. 1998:26(1) | 19 Citations (from Europe PMC, 2020-02-08)