Database Commons

a catalog of biological databases

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Database information

KinMutBase

General information

Description: KinMutBase is a registry of mutations in human protein kinases related to disorders.There are altogether 170 entries representing 273 families and 403 patients.The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations, restriction enzyme patterns and online submission.
Year founded: 1999
Last update: 2005
Version:
Accessibility:
Manual:
Accessible
Real time : Checking...
Country/Region: Finland
Data type:
Data object:
Database category:
Major organism:
NA
Keywords:

Contact information

University/Institution: Institute of Medical Technology
Address:
City:
Province/State:
Country/Region: Finland
Contact name (PI/Team): Mauno Vihinen
Contact email (PI/Helpdesk): mauno.vihinen@uta.fi

Record metadata

Created on: 2018-02-09
Curated by:
zhaohua li [2018-02-23]
pei wang [2018-02-09]

Ranking

All databases:
2111/4549 (53.616%)
Gene genome and annotation:
638/1211 (47.399%)
2111
Total Rank
50
Citations
2.381
z-index

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Not Rated
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Word cloud

Publications

15832311
KinMutBase: a registry of disease-causing mutations in protein kinase domains. [PMID: 15832311]
Ortutay C, Väliaho J, Stenberg K, Vihinen M.

A large number of disease-causing mutations have been identified from several protein kinases. KinMutBase is a comprehensive knowledge base for human disease-related mutations in protein kinase domains (http://bioinf.uta.fi/KinMutBase/). The latest version contains 582 different mutations for 1,790 cases in 1,322 families. KinMutBase entries are described on the DNA, mRNA, and protein level. Numbers for affected patients and families are also provided. KinMutBase has extensive amount of links and cross-references to literature, other databases, and information sources. There are numerous interactive pages about sequences, structures, mutation statistics, and diseases. Detailed statistical study was done on frequencies of different types of mutations both on the DNA and protein level in serine/threonine kinase (PSK) and tyrosine kinase (PTK). Three-dimensional structures indicate clustering of disease-related mutations mainly to conserved subdomains, and substrate and coligand binding amino acids, although mutations appear throughout the sequences. CpG containing codons, especially for arginine, constitute the majority of mutational hotspots. There are certain clear differences in mutation patterns and types between PSKs and PTKs.

Hum Mutat. 2005:25(5) | 42 Citations (from Europe PMC, 2020-02-08)
9847229
KinMutBase, a database of human disease-causing protein kinase mutations. [PMID: 9847229]
Stenberg KA, Riikonen PT, Vihinen M.

KinMutBase (http://www.uta.fi/laitokset/imt/KinMut Base.html) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signalling molecules, in which mutations can lead into diseases including, e.g., immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contains information for nine protein tyrosine kinases. There are altogether 170 entries representing 273 families and 403 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations, restriction enzyme patterns and online submission.

Nucleic Acids Res. 1999:27(1) | 8 Citations (from Europe PMC, 2020-02-08)