SEGreg Edit

Citations: 2

z-index: 2

Basic information
Short name SEGreg
Full name Databse of Specifically Expressed Genes and regulation
Description SEGreg is a comprehensive database containing SEGs identified by our SEGtool from four high-throughput datasets of different cancers/tissues/cell lines (TCGA, BodyMap, CCLE and GTEx), along with their corresponding miRNA and TF regulations collected from several databases. SEGreg will provide useful clues to reveal the functions and regulations of SEGs.
URL http://bioinfo.life.hust.edu.cn/SEGreg
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Huazhong University of Science and Technology
Address Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. Tel.: 86-027-87793177
City Wuhan
Province/State
Country/Region China
Contact name (PI/Team) An-Yuan Guo
Contact email (PI/Helpdesk) guoay@hust.edu.cn
Data information
Data object
Data type
Database category
Major organism
Keyword
Publications
  • SEGreg: a database for human specifically expressed genes and their regulations in cancer and normal tissue. [PMID: 29309507]
    Qin Tang, Qiong Zhang, Yao Lv, Ya-Ru Miao, An-Yuan Guo,

    Human specifically expressed genes (SEGs) usually serve as potential biomarkers for disease diagnosis and treatment. However, the regulation underlying their specific expression remains to be revealed. In this study, we constructed SEG regulation database (SEGreg; available at http://bioinfo.life.hust.edu.cn/SEGreg) for showing SEGs and their transcription factors (TFs) and microRNA (miRNA) regulations under different physiological conditions, which include normal tissue, cancer tissue and cell line. In total, SEGreg collected 6387, 1451, 4506 and 5320 SEGs from expression profiles of 34 cancer types and 55 tissues of The Cancer Genome Atlas, Cancer Cell Line Encyclopedia, Human Body Map and Genotype-Tissue Expression databases/projects, respectively. The cancer or tissue corresponding expressed miRNAs and TFs were identified from miRNA and gene expression profiles, and their targets were collected from several public resources. Then the regulatory networks of all SEGs were constructed and integrated into SEGreg. Through a user-friendly interface, users can browse and search SEGreg by gene name, data source, tissue, cancer type and regulators. In summary, SEGreg is a specialized resource to explore SEGs and their regulations, which provides clues to reveal the mechanisms of carcinogenesis and biological processes.

    Brief Bioinform 2018:()

    2 Citations (from Europe PMC, 2019-08-03)

Rank

  • Ranking in all databases: No. 2344
  • Ranking in category/categories:
    • Expression: No. 418
    • Modification: No. 108
    • Metadata: No. 194
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of SEGreg.

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Record metadata

  • Created on: 2018-01-29
    • ***ahnazir@***u.edu.pk [2018-04-13]

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