pronto Edit

Citations: 5

z-index: 1.25

Basic information
Short name pronto
Full name
Description PrOnto is a tool to query Gene Ontology term pair functional dissimilarity based on real biological data. GO terms that co-occur less than expected by chance in a species' annotations (annotation probabilities) or in its protein-protein interaction network (interaction probabilities) are considered functionally dissimilar.
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Aix Marseille University
Address Inserm, UMR_S1090 TAGC Marseille, France ; Aix-Marseille Université, UMR_S1090 TAGC Marseille, France ; Centre National de la Recherche Scientifique Marseille, France
Country/Region France
Contact name (PI/Team) Brun C
Contact email (PI/Helpdesk)
Data information
Data object
Data type
Database category
Major organism
  • PrOnto database : GO term functional dissimilarity inferred from biological data. [PMID: 26089836]
    Charles E Chapple, Carl Herrmann, Christine Brun,

    Moonlighting proteins are defined by their involvement in multiple, unrelated functions. The computational prediction of such proteins requires a formal method of assessing the similarity of cellular processes, for example, by identifying dissimilar Gene Ontology terms. While many measures of Gene Ontology term similarity exist, most depend on abstract mathematical analyses of the structure of the GO tree and do not necessarily represent the underlying biology. Here, we propose two metrics of GO term functional dissimilarity derived from biological information, one based on the protein annotations and the other on the interactions between proteins. They have been collected in the PrOnto database, a novel tool which can be of particular use for the identification of moonlighting proteins. The database can be queried via an web-based interface which is freely available at

    Front Genet 2015:6()

    5 Citations (from Europe PMC, 2019-07-13)


  • Ranking in all databases: No. 2884
  • Ranking in category/categories:
    • Standard ontology and nomenclature: No. 120
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of pronto.

Word cloud

Related Database



Record metadata

  • Created on: 2018-01-29
    • ***ina@*** [2019-01-29]
    • ***ina@*** [2019-01-29]
    • ***arafique@*** [2018-04-11]

Community reviews 0 stars (0 reviews)

quality & quantity
organization & presentation
accessibility & reliability
Reviewed by