Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

RNA editing

General information

Description: Adenine to Inosine RNA editing is a widespread co- and post-transcriptional mechanism mediated by ADAR enzymes acting on double stranded RNA. It has a plethora of biological effects, appears to be particularly pervasive in humans with respect to other mammals, and is implicated in a number of diverse human pathologies
Year founded: 2015
Last update:
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Country/Region: Italy
Data type:
RNA
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Contact information

University/Institution: University of Bari
Address: Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Via Orabona 4, 70126 Bari, Italy
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Country/Region: Italy
Contact name (PI/Team): Graziano Pesole
Contact email (PI/Helpdesk): graziano.pesole@biology.uniba.it

Record metadata

Created on: 2018-01-29
Curated by:
Alia Rafique [2018-04-11]

Ranking

All databases:
722/4549 (84.15%)
Expression:
124/800 (84.625%)
722
Total Rank
48
Citations
9.6
z-index

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Publications

26449202
Profiling RNA editing in human tissues: towards the inosinome Atlas. [PMID: 26449202]
Picardi E, Manzari C, Mastropasqua F, Aiello I, D'Erchia AM, Pesole G.

Adenine to Inosine RNA editing is a widespread co- and post-transcriptional mechanism mediated by ADAR enzymes acting on double stranded RNA. It has a plethora of biological effects, appears to be particularly pervasive in humans with respect to other mammals, and is implicated in a number of diverse human pathologies. Here we present the first human inosinome atlas comprising 3,041,422 A-to-I events identified in six tissues from three healthy individuals. Matched directional total-RNA-Seq and whole genome sequence datasets were generated and analysed within a dedicated computational framework, also capable of detecting hyper-edited reads. Inosinome profiles are tissue specific and edited gene sets consistently show enrichment of genes involved in neurological disorders and cancer. Overall frequency of editing also varies, but is strongly correlated with ADAR expression levels. The inosinome database is available at: http://srv00.ibbe.cnr.it/editing/.

Sci Rep. 2015:5() | 48 Citations (from Europe PMC, 2020-02-08)