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a catalog of biological databases

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Database information

Histome (The Histone Infobase)

General information

Description: HIstome is a freely available, specialist, electronic database dedicated to display infomation about human histone variants, sites of their post-translational modifications and about various histone modifying enzymes.
Year founded: 2011
Last update: 2011-10-28
Version: v1.0
Accessibility:
Manual:
Accessible
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Country/Region: India
Data type:
Data object:
Database category:
Major organism:
Keywords:

Contact information

University/Institution: Cancer Research Institute
Address: Advanced Centre for Treatment,Research and Education in Cancer (ACTREC),Kharghar,Navi Mumbai 410210,India
City: Mumbai
Province/State:
Country/Region: India
Contact name (PI/Team): Sanjay Gupta
Contact email (PI/Helpdesk): sgupta@actrec.gov.in

Record metadata

Created on: 2015-06-20
Curated by:
Chunlei Yu [2016-03-31]
Chunlei Yu [2015-11-19]
Chunlei Yu [2015-06-27]

Ranking

All databases:
1064/4549 (76.632%)
Modification:
46/185 (75.676%)
1064
Total Rank
48
Citations
6
z-index

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Publications

22140112
HIstome--a relational knowledgebase of human histone proteins and histone modifying enzymes. [PMID: 22140112]
Khare SP, Habib F, Sharma R, Gadewal N, Gupta S, Galande S.

Histones are abundant nuclear proteins that are essential for the packaging of eukaryotic DNA into chromosomes. Different histone variants, in combination with their modification 'code', control regulation of gene expression in diverse cellular processes. Several enzymes that catalyze the addition and removal of multiple histone modifications have been discovered in the past decade, enabling investigations of their role(s) in normal cellular processes and diverse pathological conditions. This sudden influx of data, however, has resulted in need of an updated knowledgebase that compiles, organizes and presents curated scientific information to the user in an easily accessible format. Here, we present HIstome, a browsable, manually curated, relational database that provides information about human histone proteins, their sites of modifications, variants and modifying enzymes. HIstome is a knowledgebase of 55 human histone proteins, 106 distinct sites of their post-translational modifications (PTMs) and 152 histone-modifying enzymes. Entries have been grouped into 5 types of histones, 8 types of post-translational modifications and 14 types of enzymes that catalyze addition and removal of these modifications. The resource will be useful for epigeneticists, pharmacologists and clinicians. HIstome: The Histone Infobase is available online at http://www.iiserpune.ac.in/?coee/histome/ and http://www.actrec.gov.in/histome/.

Nucleic Acids Res. 2012:40(Database issue) | 48 Citations (from Europe PMC, 2020-02-15)