MiCroKiTS Edit

Citations: 25

z-index: 2.78

Basic information
Short name MiCroKiTS
Full name Midbody,Centrosome,Kinetochore,Telomere and Spindle
Description A database for proteins temporally and spatially localized in distinct subcellular positions including midbody,centrosome,kinetochore,telomere and mitotic spindle during cell division/mitosis
URL http://microkit.biocuckoo.org/
Year founded 2010
Last update & version 9/6/2014 v4.0
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Huazhong University of Science and Technology
Address Wuhan,Hubei 430074,China
City Wuhan
Province/State Hubei
Country/Region China
Contact name (PI/Team) Yu Xue
Contact email (PI/Helpdesk) xueyu@hust.edu.cn
Data information
Data object
Data type
Database category
Major organism
  • MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle. [PMID: 25392421]
    Zhengnan Huang, Lili Ma, Yongbo Wang, Zhicheng Pan, Jian Ren, Zexian Liu, Yu Xue

    We reported an updated database of MiCroKiTS 4.0 (http://microkit.biocuckoo.org) for proteins temporally and spatially localized in distinct subcellular positions including midbody, centrosome, kinetochore, telomere and mitotic spindle during cell division/mitosis. The database was updated from our previously developed database of MiCroKit 3.0, which contained 1489 proteins mostly forming super-complexes at midbody, centrosome and kinetochore from seven eukaryotes. Since the telomere and spindle apparatus are critical for cell division, the proteins localized at the two positions were also integrated. From the scientific literature, we curated 1872 experimentally identified proteins which at least locate in one of the five positions from eight species. Then the ortholog detection was performed to identify potential MiCroKiTS proteins from 144 eukaryotic organisms, which contains 66, 45 and 33 species of animals, fungi and plants, respectively. In total, 87,983 unique proteins with corresponding localization information were integrated into the database. The primary references of experimentally identified localizations were provided and the fluorescence microscope figures for the localizations of human proteins were shown. The orthologous relations between predicted and experimental localizations were also present. Taken together, we anticipate the database can serve as a useful resource for further analyzing the molecular mechanisms during cell division. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

    Nucleic Acids Res 2015:43(Database issue)

    9 Citations (from Europe PMC, 2019-08-03)

  • MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore. [PMID: 19783819]
    Jian Ren, Zexian Liu, Xinjiao Gao, Changjiang Jin, Mingliang Ye, Hanfa Zou, Longping Wen, Zhaolei Zhang, Yu Xue, Xuebiao Yao

    During cell division/mitosis, a specific subset of proteins is spatially and temporally assembled into protein super complexes in three distinct regions, i.e. centrosome/spindle pole, kinetochore/centromere and midbody/cleavage furrow/phragmoplast/bud neck, and modulates cell division process faithfully. Although many experimental efforts have been carried out to investigate the characteristics of these proteins, no integrated database was available. Here, we present the MiCroKit database (http://microkit.biocuckoo.org) of proteins that localize in midbody, centrosome and/or kinetochore. We collected into the MiCroKit database experimentally verified microkit proteins from the scientific literature that have unambiguous supportive evidence for subcellular localization under fluorescent microscope. The current version of MiCroKit 3.0 provides detailed information for 1489 microkit proteins from seven model organisms, including Saccharomyces cerevisiae, Schizasaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Mus musculus and Homo sapiens. Moreover, the orthologous information was provided for these microkit proteins, and could be a useful resource for further experimental identification. The online service of MiCroKit database was implemented in PHP + MySQL + JavaScript, while the local packages were developed in JAVA 1.5 (J2SE 5.0).

    Nucleic Acids Res 2010:38(Database issue)

    16 Citations (from Europe PMC, 2019-08-03)


  • Ranking in all databases: No. 1910
  • Ranking in category/categories:
    • Gene genome and annotation: No. 587
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of MiCroKiTS.

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Record metadata

  • Created on: 2015-06-20
    • ***ina@***c.cn [2018-06-14]
    • ***lin@***c.cn [2016-03-29]
    • ***ang@***c.cn [2015-06-26]
    • ***gj@***c.cn [2015-06-26]

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