thanatos Edit

Citations: 3

z-index: 1.5

Basic information
Short name thanatos
Full name thanatos
Description THe Autophagy, Necrosis, ApopTosis OrchestratorS
Year founded 2017
Last update & version 2017
Availability Free to all users
Contact information
University/Institution hosted Huazhong University of Science and Technology
Address huazhong university of science and technology (hust)
Country/Region China
Contact name yu xue
Contact email
Data information
Data object
  • Animal
  • Plant
  • Fungi
Data type
  • Other
Database category
  • Expression
  • Literature
Major organism
  • Mus musculus
  • necrosis
  • apoptosis
  • THANATOS: an integrative data resource of proteins and post-translational modifications in the regulation of autophagy. [PMID: 29157087]
    Wankun Deng, Lili Ma, Ying Zhang, Jiaqi Zhou, Yongbo Wang, Zexian Liu, Yu Xue,

    Macroautophagy/autophagy is a highly conserved process for degrading cytoplasmic contents, determines cell survival or death, and regulates the cellular homeostasis. Besides ATG proteins, numerous regulators together with various post-translational modifications (PTMs) are also involved in autophagy. In this work, we collected 4,237 experimentally identified proteins regulated in autophagy and cell death pathways from the literature. Then we computationally identified potential orthologs of known proteins, and developed a comprehensive database of The Autophagy, Necrosis, ApopTosis OrchestratorS (THANATOS, ), containing 191,543 proteins potentially associated with autophagy cell death pathways in 164 eukaryotes. We performed an evolutionary analysis of ATG genes, and observed that ATGs required for the autophagosome formation are highly conserved across eukaryotes. Further analyses revealed that known cancer genes and drug targets were overrepresented in human autophagy proteins, which were significantly associated in a number of signaling pathways and human diseases. By reconstructing a human kinase-substrate phosphorylation network for ATG proteins, our results confirmed that phosphorylation play a critical role in regulating autophagy. In total, we mapped 65,015 known sites of 11 types of PTMs to collected proteins, and revealed that all types of PTM substrates were enriched in human autophagy. In addition, we observed multiple types of PTM regulators such as protein kinases and ubiquitin E3 ligases or adaptors were significantly associated with human autophagy, and again the results emphasized the importance of PTM regulations in autophagy. We anticipated THANATOS can be a useful resource for further studies.

    Autophagy 2017:()

    3 Citations (from Europe PMC, 2019-01-26)

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Record metadata

  • Created on: 2018-01-28
    • ***ashireen@*** [2018-04-12]
    • ***ngyang17m@*** [2018-01-28]

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