LncRNADisease Edit

Citations: 285

z-index: 57

Basic information
Short name LncRNADisease
Full name Database on lncRNA-disease associations
Description The LncRNADisease database is not only a resource that curated the experimentally supported lncRNA-disease association data but also a platform that integrated tool(s) for predicting novel lncRNA-disease associatons.
URL http://www.rnanut.net/lncrnadisease/
Year founded 2012
Last update & version 2018-05-10 v1.0
Availability Free to all users
Contact information
University/Institution hosted Peking University
Address 38 Xueyuan Road,Beijing,100190,China
City Beijing
Province/State
Country/Region China
Contact name Qinghua Cui
Contact email cuiqinghua@hsc.pku.edu.cn
Data information
Data object
  • Animal
Data type
  • RNA
Database category
  • Health and medicine
Major organism
  • Homo sapiens
Keyword
  • lncRNA-disease association
Publications
  • LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases. [PMID: 30285109]
    Zhenyu Bao, Zhen Yang, Zhou Huang, Yiran Zhou, Qinghua Cui, Dong Dong

    Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety of diseases. A knowledgebase with systematic collection and curation of lncRNA-disease associations is critically important for further examining their underlying molecular mechanisms. In 2013, we presented the first release of LncRNADisease, representing a database for collection of experimental supported lncRNA-disease associations. Here, we describe an update of the database. The new developments in LncRNADisease 2.0 include (i) an over 40-fold lncRNA-disease association enhancement compared with the previous version; (ii) providing the transcriptional regulatory relationships among lncRNA, mRNA and miRNA; (iii) providing a confidence score for each lncRNA-disease association; (iv) integrating experimentally supported circular RNA disease associations. LncRNADisease 2.0 documents more than 200 000 lncRNA-disease associations. We expect that this database will continue to serve as a valuable source for potential clinical application related to lncRNAs. LncRNADisease 2.0 is freely available at http://www.rnanut.net/lncrnadisease/.

    Nucleic Acids Res. 2018:()

    0 Citations (from Europe PMC, 2018-12-08)

  • LncRNADisease: a database for long-non-coding RNA-associated diseases. [PMID: 23175614]
    Geng Chen, Ziyun Wang, Dongqing Wang, Chengxiang Qiu, Mingxi Liu, Xing Chen, Qipeng Zhang, Guiying Yan, Qinghua Cui

    In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs' roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA-disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA-disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA-disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA-disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database.

    Nucleic acids research 2013:41(Database issue)

    285 Citations (from Europe PMC, 2018-12-08)

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Record metadata

  • Created on: 2015-06-20
    • ***qinghua@***ku.edu.cn [2018-11-27]
    • ***ina@***c.cn [2018-05-10]
    • ***hunlei@***c.cn [2016-04-01]
    • ***ng***ng@***c.cn [2016-03-05]
    • ***hunlei@***c.cn [2015-06-29]

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