LncRNADisease Edit

Citations: 304

z-index: 50.67

Basic information
Short name LncRNADisease
Full name Database on lncRNA-disease associations
Description The LncRNADisease database is not only a resource that curated the experimentally supported lncRNA-disease association data but also a platform that integrated tool(s) for predicting novel lncRNA-disease associatons.
URL http://www.rnanut.net/lncrnadisease/
Year founded 2012
Last update & version 2018-05-10 v1.0
Availability Free to all users
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Peking University
Address 38 Xueyuan Road,Beijing,100190,China
City Beijing
Province/State
Country/Region China
Contact name (PI/Team) Qinghua Cui
Contact email (PI/Helpdesk) cuiqinghua@hsc.pku.edu.cn
Data information
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Data type
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Publications
  • LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases. [PMID: 30285109]
    Zhenyu Bao, Zhen Yang, Zhou Huang, Yiran Zhou, Qinghua Cui, Dong Dong

    Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety of diseases. A knowledgebase with systematic collection and curation of lncRNA-disease associations is critically important for further examining their underlying molecular mechanisms. In 2013, we presented the first release of LncRNADisease, representing a database for collection of experimental supported lncRNA-disease associations. Here, we describe an update of the database. The new developments in LncRNADisease 2.0 include (i) an over 40-fold lncRNA-disease association enhancement compared with the previous version; (ii) providing the transcriptional regulatory relationships among lncRNA, mRNA and miRNA; (iii) providing a confidence score for each lncRNA-disease association; (iv) integrating experimentally supported circular RNA disease associations. LncRNADisease 2.0 documents more than 200 000 lncRNA-disease associations. We expect that this database will continue to serve as a valuable source for potential clinical application related to lncRNAs. LncRNADisease 2.0 is freely available at http://www.rnanut.net/lncrnadisease/.

    Nucleic Acids Res 2019:47(D1)

    0 Citations (from Europe PMC, 2019-05-18)

  • LncRNADisease: a database for long-non-coding RNA-associated diseases. [PMID: 23175614]
    Geng Chen, Ziyun Wang, Dongqing Wang, Chengxiang Qiu, Mingxi Liu, Xing Chen, Qipeng Zhang, Guiying Yan, Qinghua Cui

    In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs' roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA-disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA-disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA-disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA-disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database.

    Nucleic Acids Res 2013:41(Database issue)

    304 Citations (from Europe PMC, 2019-05-25)

Rank

  • Ranking in all databases: No. 148
  • Ranking in category/categories:
    • Health and medicine: No. 23
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of LncRNADisease.

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Record metadata

  • Created on: 2015-06-20
    • ***qinghua@***ku.edu.cn [2018-11-27]
    • ***ina@***c.cn [2018-05-10]
    • ***hunlei@***c.cn [2016-04-01]
    • ***ng***ng@***c.cn [2016-03-05]
    • ***hunlei@***c.cn [2015-06-29]

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