iUUCD Edit

Citations: 1

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Basic information
Short name iUUCD
Full name integrated annotations for Ubiquitin and Ubiquitin-like Conjugation Database
Description The released iUUCD (integrated annotations for Ubiquitin and Ubiquitin-like Conjugation Database, ver 2.0) is an updated systematic resource for ubiquitin and ubiquitin-like conjugations. 27 E1s, 109 E2s, 1,153 E3s, 164 DUBs, 396 UBDs and 183 ULDs were collected from scientific literatures and classified into 1, 4, 23, 8, 27, 11 families, respectively. The newly release added 6 new families for E2, E3 and DUB enzymes, as well as a hierarchical classification for UBD and ULD families.
URL http://iuucd.biocuckoo.org
Year founded
Last update & version 2017 2.0
Availability Free to all users
Contact information
University/Institution hosted Huazhong University of Science and Technology
Address Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology and the Collaborative Innovation Center for Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
City
Province/State
Country/Region China
Contact name Yu Xue
Contact email xueyu@hust.edu.cn
Data information
Object(s)
  • Animal
  • Plant
  • Fungi
Data type(s)
  • Protein
Data Category/Categories
  • Gene genome and annotation
  • Genotype phenotype and variation
  • Expression
  • Modification
  • Interaction
Major organism(s)
  • Homo sapiens
  • Pan troglodytes
  • Mus musculus
  • Oryza sativa
  • Zea mays
  • Dothistroma septosporum
  • Aspergillus flavus
Keyword(s)
  • ubiquitin
  • ubiquitin conjugation
  • ubiquitin-activating enzymes
  • deubiquitinating enzymes
  • ubiquitin-binding domain containing proteins
Publications
  • iUUCD 2.0: an update with rich annotations for ubiquitin and ubiquitin-like conjugations.[PMID: 29106644]
    Jiaqi Zhou, Yang Xu, Shaofeng Lin, Yaping Guo, Wankun Deng, Ying Zhang, Anyuan Guo, Yu Xue,

    Here, we described the updated database iUUCD 2.0 (http://iuucd.biocuckoo.org/) for ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), ubiquitin-protein ligases (E3s), deubiquitinating enzymes (DUBs), ubiquitin/ubiquitin-like binding domains (UBDs) and ubiquitin-like domains (ULDs), which act as key regulators in modulating ubiquitin and ubiquitin-like (UB/UBL) conjugations. In total, iUUCD 2.0 contained 136 512 UB/UBL regulators, including 1230 E1s, 5636 E2s, 93 343 E3s, 9548 DUBs, 30 173 UBDs and 11 099 ULDs in 148 eukaryotic species. In particular, we provided rich annotations for regulators of eight model organisms, especially in humans, by compiling and integrating the knowledge from nearly 70 widely used public databases that cover cancer mutations, single nucleotide polymorphisms (SNPs), mRNA expression, DNA and RNA elements, protein-protein interactions, protein 3D structures, disease-associated information, drug-target relations, post-translational modifications, DNA methylation and protein expression/proteomics. Compared with our previously developed UUCD 1.0 (∼0.41 GB), iUUCD 2.0 has a size of ∼32.1 GB of data with a >75-fold increase in data volume. We anticipate that iUUCD 2.0 can be a more useful resource for further study of UB/UBL conjugations.

    Nucleic Acids Res. 2017:()

    1 Citations (from Europe PMC, 2018-10-12)

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Record metadata

  • Created on: 2018-01-28
    • Batool Fatima [2018-04-13]

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