TCMSP Edit

Citations: 123

z-index: 24.6

Basic information
Short name TCMSP
Full name a database of systems pharmacology for drug discovery from herbal medicines
Description The traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was built based on the framework of systems pharmacology for herbal medicines. It consists of all the 499 Chinese herbs registered in the Chinese pharmacopoeia with 29,384 ingredients, 3,311 targets and 837 associated diseases. Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier and Lipinski's rule of five are provided for drug screening and evaluation. TCMSP also provides drug targets and diseases of each active compound, which can automatically establish the compound-target and target-disease networks that let users view and analyze the drug action mechanisms. It is designed to fuel the development of herbal medicines and to promote integration of modern medicine and traditional medicine for drug discovery and development.
URL http://lsp.nwu.edu.cn/tcmsp.php?tdsourcetag=s_pcqq_aiomsg
Year founded
Last update & version
Availability Free to academic users only
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Northwest A&F University
Address Center for Bioinformatics, College of Life Science, Northwest A&F University, Yangling, China
City
Province/State
Country/Region China
Contact name (PI/Team) Yonghua Wang
Contact email (PI/Helpdesk) yh_wang@nwsuaf.edu.cn
Data information
Data object
Data type
Database category
Major organism
Keyword
Publications
  • TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. [PMID: 24735618]
    Jinlong Ru, Peng Li, Jinan Wang, Wei Zhou, Bohui Li, Chao Huang, Pidong Li, Zihu Guo, Weiyang Tao, Yinfeng Yang, Xue Xu, Yan Li, Yonghua Wang, Ling Yang,

    BACKGROUND: Modern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate the drug discovery from herbal medicines, an efficient systems pharmacology platform that represents ideal information convergence of pharmacochemistry, ADME properties, drug-likeness, drug targets, associated diseases and interaction networks, are urgently needed.
    DESCRIPTION: The traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was built based on the framework of systems pharmacology for herbal medicines. It consists of all the 499 Chinese herbs registered in the Chinese pharmacopoeia with 29,384 ingredients, 3,311 targets and 837 associated diseases. Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier and Lipinski's rule of five are provided for drug screening and evaluation. TCMSP also provides drug targets and diseases of each active compound, which can automatically establish the compound-target and target-disease networks that let users view and analyze the drug action mechanisms. It is designed to fuel the development of herbal medicines and to promote integration of modern medicine and traditional medicine for drug discovery and development.
    CONCLUSIONS: The particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature of TCM theory and developing new herb-oriented drugs. TCMSP is freely available at http://sm.nwsuaf.edu.cn/lsp/tcmsp.php.

    J Cheminform 2014:6()

    123 Citations (from Europe PMC, 2019-05-18)

Rank

  • Ranking in all databases: No. 288
  • Ranking in category/categories:
    • Health and medicine: No. 53
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of TCMSP.

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Record metadata

  • Created on: 2018-01-28
    • ***ina@***c.cn [2019-05-14]
    • ***sardar@***u.edu.pk [2018-04-11]
    • ***sardar@***u.edu.pk [2018-04-10]
    • ***gqi17m@***c.cn [2018-01-27]

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