Yeast database Edit

Citations: 29

z-index: 5.8

Basic information
Short name Yeast database
Full name
Description Yeast 6 comprises 1458 metabolites participating in 1888 reactions, which are annotated with 900 yeast genes encoding the catalyzing enzymes. Compared with Yeast 5, Yeast 6 demonstrates improved sensitivity, specificity and positive and negative predictive values for predicting gene essentiality in glucose-limited aerobic conditions when analyzed with flux balance analysis.
URL http://yeast.sf.net/
Year founded
Last update & version 6.0
Availability Free to academic users only
Contact information
University/Institution hosted Institute for Systems Biology
Address
City Seattle
Province/State Washington
Country/Region United States
Contact name Larry P. Walker
Contact email lpw1@cornell.edu
Data information
Object(s)
  • Fungi
Data type(s)
  • DNA
  • RNA
  • Protein
Data Category/Categories
  • Pathway
Major organism(s)
  • Saccharomyces cerevisiae
Keyword(s)
  • metabolic network
Publications
  • Version 6 of the consensus yeast metabolic network refines biochemical coverage and improves model performance.[PMID: 23935056]
    Benjamin D Heavner, Kieran Smallbone, Nathan D Price, Larry P Walker,

    Updates to maintain a state-of-the art reconstruction of the yeast metabolic network are essential to reflect our understanding of yeast metabolism and functional organization, to eliminate any inaccuracies identified in earlier iterations, to improve predictive accuracy and to continue to expand into novel subsystems to extend the comprehensiveness of the model. Here, we present version 6 of the consensus yeast metabolic network (Yeast 6) as an update to the community effort to computationally reconstruct the genome-scale metabolic network of Saccharomyces cerevisiae S288c. Yeast 6 comprises 1458 metabolites participating in 1888 reactions, which are annotated with 900 yeast genes encoding the catalyzing enzymes. Compared with Yeast 5, Yeast 6 demonstrates improved sensitivity, specificity and positive and negative predictive values for predicting gene essentiality in glucose-limited aerobic conditions when analyzed with flux balance analysis. Additionally, Yeast 6 improves the accuracy of predicting the likelihood that a mutation will cause auxotrophy. The network reconstruction is available as a Systems Biology Markup Language (SBML) file enriched with Minimium Information Requested in the Annotation of Biochemical Models (MIRIAM)-compliant annotations. Small- and macromolecules in the network are referenced to authoritative databases such as Uniprot or ChEBI. Molecules and reactions are also annotated with appropriate publications that contain supporting evidence. Yeast 6 is freely available at http://yeast.sf.net/ as three separate SBML files: a model using the SBML level 3 Flux Balance Constraint package, a model compatible with the MATLABĀ® COBRA Toolbox for backward compatibility and a reconstruction containing only reactions for which there is experimental evidence (without the non-biological reactions necessary for simulating growth). Database URL: http://yeast.sf.net/

    Database (Oxford) 2013:2013()

    29 Citations (from Europe PMC, 2018-09-21)

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Record metadata

  • Created on: 2018-01-27
    • xiong zhuang [2018-07-11]
    • Ma Lina [2018-07-11]
    • Ma Lina [2018-07-11]
    • xiong zhuang [2018-02-24]

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