DoriC Edit

Citations: 119

z-index: 10.82

Basic information
Short name DoriC
Full name Database of oriC regions in Bacterial and Archaeal genomes
Description DoriC provides extensive information and graphical views of the origins of replication (oriCs).
Year founded 2007
Last update & version 2013-4-6 v6.5
Availability Free to all users
Contact information
University/Institution hosted Tianjin University
Address Department of Physics, Tianjin University, Tianjin 300072, China
City Tianjin
Country/Region China
Contact name Feng Gao
Contact email
Data information
  • Bacteria
  • Archaea
Data type(s)
  • DNA
Data Category/Categories
  • Gene genome and annotation
Major organism(s)
  • NA
  • Ori-Finder
  • origins of replication (oriCs)
  • DoriC 5.0: an updated database of oriC regions in both bacterial and archaeal genomes.[PMID: 23093601]
    Feng Gao, Hao Luo, Chun-Ting Zhang

    Replication of chromosomes is one of the central events in the cell cycle. Chromosome replication begins at specific sites, called origins of replication (oriCs), for all three domains of life. However, the origins of replication still remain unknown in a considerably large number of bacterial and archaeal genomes completely sequenced so far. The availability of increasing complete bacterial and archaeal genomes has created challenges and opportunities for identification of their oriCs in silico, as well as in vivo. Based on the Z-curve theory, we have developed a web-based system Ori-Finder to predict oriCs in bacterial genomes with high accuracy and reliability by taking advantage of comparative genomics, and the predicted oriC regions have been organized into an online database DoriC, which is publicly available at since 2007. Five years after we constructed DoriC, the database has significant advances over the number of bacterial genomes, increasing about 4-fold. Additionally, oriC regions in archaeal genomes identified by in vivo experiments, as well as in silico analyses, have also been added to the database. Consequently, the latest release of DoriC contains oriCs for >1500 bacterial genomes and 81 archaeal genomes, respectively.

    Nucleic acids research 2013:41(Database issue)

    66 Citations (from Europe PMC, 2018-10-12)

  • DoriC: a database of oriC regions in bacterial genomes.[PMID: 17496319]
    Feng Gao, Chun-Ting Zhang

    Replication origins (oriCs) of bacterial genomes currently available in GenBank have been predicted by using a systematic method comprising the Z-curve analysis for nucleotide distribution asymmetry, DnaA box distribution, genes adjacent to candidate oriCs and phylogenetic relationships. These oriCs are organized into a MySQL database, DoriC, which provides extensive information and graphical views of the oriC regions. In addition, users can Blast a query sequence or even a whole genome against DoriC to find a homologous one. DoriC will be updated timely and the latest version is DoriC 1.8, in which oriCs of 425 genomes (468 chromosomes) are identified. DoriC can be accessed from Supplementary data are available at

    Bioinformatics (Oxford, England) 2007:23(14)

    53 Citations (from Europe PMC, 2018-10-12)

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Record metadata

  • Created on: 2015-06-21
    • Ma Lina [2018-06-11]
    • SA Jian [2016-04-04]
    • Zhang Zhang [2015-12-30]
    • SA Jian [2015-12-07]
    • SA Jian [2015-06-26]

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