InvFEST Edit

Citations: 17

z-index: 4.25

Basic information
Short name InvFEST
Full name Human Polymorphic Inversion DataBase
Description InvFEST aims to become a reference site to share information and collaborate towards the complete characterization of human polymorphic inversions.
URL http://invfestdb.uab.cat/
Year founded 2013
Last update & version 2014-11-25 v1.0
Availability Free to all users
Contact information
University/Institution hosted Universitat Autònoma de Barcelona
Address Comparative and Functional Genomics group, Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
City Barcelona
Province/State
Country/Region Spain
Contact name Administrator
Contact email invfestdb@uab.cat
Data information
Object(s)
  • Animal
Data type(s)
  • DNA
Data Category/Categories
  • Genotype phenotype and variation
  • Structure
Major organism(s)
  • Homo sapiens
Keyword(s)
  • breakpoint location
  • polymorphic inversion
Publications
  • InvFEST, a database integrating information of polymorphic inversions in the human genome.[PMID: 24253300]
    Alexander Martínez-Fundichely, Sònia Casillas, Raquel Egea, Miquel Ràmia, Antonio Barbadilla, Lorena Pantano, Marta Puig, Mario Cáceres

    The newest genomic advances have uncovered an unprecedented degree of structural variation throughout genomes, with great amounts of data accumulating rapidly. Here we introduce InvFEST (http://invfestdb.uab.cat), a database combining multiple sources of information to generate a complete catalogue of non-redundant human polymorphic inversions. Due to the complexity of this type of changes and the underlying high false-positive discovery rate, it is necessary to integrate all the available data to get a reliable estimate of the real number of inversions. InvFEST automatically merges predictions into different inversions, refines the breakpoint locations, and finds associations with genes and segmental duplications. In addition, it includes data on experimental validation, population frequency, functional effects and evolutionary history. All this information is readily accessible through a complete and user-friendly web report for each inversion. In its current version, InvFEST combines information from 34 different studies and contains 1092 candidate inversions, which are categorized based on internal scores and manual curation. Therefore, InvFEST aims to represent the most reliable set of human inversions and become a central repository to share information, guide future studies and contribute to the analysis of the functional and evolutionary impact of inversions on the human genome.

    Nucleic acids research 2014:42(Database issue)

    17 Citations (from Europe PMC, 2018-06-22)

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Record metadata

  • Created on: 2015-06-21
    • Yu Chunlei [2015-06-29]
    • Yu Chunlei [2015-11-20]
    • Yu Chunlei [2016-04-17]
    • Li Mengwei [2016-02-19]
    • Ma Lina [2018-06-14]

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