WERAM Edit

Citations: 7

z-index: 7

Basic information
Short name WERAM
Full name Writers, Erasers and Readers of Acetylation & Methylation
Description WERAM is a database for histone acetyltransferases, histone deacetylases, histone methyltransferases, histone demethylases and acetyl- or methyl-binding proteins, which catalyze, remove and recognize histone acetylation and methylation sites as ‘writers’, ‘erasers’ and ‘readers’, and synergistically determine the ‘histone code’.
URL http://weram.biocuckoo.org/
Year founded 2016
Last update & version 2016-09-26 v1.0
Availability Free to all users
Contact information
University/Institution hosted Huazhong University of Science and Technology
Address No. 1037, Luoyu Road
City Wuhan
Province/State Hubei
Country/Region China
Contact name Yu Xue
Contact email xueyu@hust.edu.cn
Data information
Object(s)
Data type(s)
  • Protein
Data Category/Categories
  • Modification
Major organism(s)
Keyword(s)
  • acetylation
  • methylation
Publications
  • WERAM: a database of writers, erasers and readers of histone acetylation and methylation in eukaryotes.[PMID: 27789692]
    Yang Xu, Shuang Zhang, Shaofeng Lin, Yaping Guo, Wankun Deng, Ying Zhang, Yu Xue

    In this work, we developed a database WERAM (http://weram.biocuckoo.org/) for histone acetyltransferases, histone deacetylases, histone methyltransferases, histone demethylases and acetyl- or methyl-binding proteins, which catalyze, remove and recognize histone acetylation and methylation sites as 'writers', 'erasers' and 'readers', and synergistically determine the 'histone code'. From the scientific literature, we totally collected over 580 experimentally identified histone regulators from eight model organisms, including Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, Schizosaccharomyces pombe and Saccharomyces cerevisiae We also collected ∼900 site-specific regulator-histone relations from the eight species. According to the experimental evidence, known histone regulators were classified into distinct families. To computationally detect more proteins in eukaryotes, we constructed hidden Markov model (HMM) profiles for histone regulator families. For families without HMM profiles, we also conducted orthologous searches. Totally, WERAM database contained more than 20 thousand non-redundant histone regulators from 148 eukaryotes. The detailed annotations and classification information of histone regulators were provided, together with site-specific histone substrates if available. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

    Nucleic acids research 2017:45(D1)

    7 Citations (from Europe PMC, 2018-10-12)

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Record metadata

  • Created on: 2017-02-16
    • Sun Shixiang [2017-02-15]

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