WERAM Edit

Citations: 8

z-index: 4

Basic information
Short name WERAM
Full name Writers, Erasers and Readers of Acetylation & Methylation
Description WERAM is a database for histone acetyltransferases, histone deacetylases, histone methyltransferases, histone demethylases and acetyl- or methyl-binding proteins, which catalyze, remove and recognize histone acetylation and methylation sites as ‘writers’, ‘erasers’ and ‘readers’, and synergistically determine the ‘histone code’.
URL http://weram.biocuckoo.org/
Year founded 2016
Last update & version 2016-09-26 v1.0
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Huazhong University of Science and Technology
Address No. 1037, Luoyu Road
City Wuhan
Province/State Hubei
Country/Region China
Contact name (PI/Team) Yu Xue
Contact email (PI/Helpdesk) xueyu@hust.edu.cn
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Publications
  • WERAM: a database of writers, erasers and readers of histone acetylation and methylation in eukaryotes. [PMID: 27789692]
    Yang Xu, Shuang Zhang, Shaofeng Lin, Yaping Guo, Wankun Deng, Ying Zhang, Yu Xue

    In this work, we developed a database WERAM (http://weram.biocuckoo.org/) for histone acetyltransferases, histone deacetylases, histone methyltransferases, histone demethylases and acetyl- or methyl-binding proteins, which catalyze, remove and recognize histone acetylation and methylation sites as 'writers', 'erasers' and 'readers', and synergistically determine the 'histone code'. From the scientific literature, we totally collected over 580 experimentally identified histone regulators from eight model organisms, including Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, Schizosaccharomyces pombe and Saccharomyces cerevisiae We also collected ?900 site-specific regulator-histone relations from the eight species. According to the experimental evidence, known histone regulators were classified into distinct families. To computationally detect more proteins in eukaryotes, we constructed hidden Markov model (HMM) profiles for histone regulator families. For families without HMM profiles, we also conducted orthologous searches. Totally, WERAM database contained more than 20 thousand non-redundant histone regulators from 148 eukaryotes. The detailed annotations and classification information of histone regulators were provided, together with site-specific histone substrates if available. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

    Nucleic Acids Res 2017:45(D1)

    8 Citations (from Europe PMC, 2019-08-03)

Rank

  • Ranking in all databases: No. 1508
  • Ranking in category/categories:
    • Modification: No. 63
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of WERAM.

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Record metadata

  • Created on: 2017-02-15
    • ***shx@***c.cn [2017-02-15]

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