GtoPdb Edit

Citations: 842

z-index: 280.67

Basic information
Short name GtoPdb
Full name IUPHAR/BPS Guide to PHARMACOLOGY
Description The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome.
URL http://www.guidetopharmacology.org/
Year founded 2015
Last update & version 2018-5-9 v2018.2
Availability Free to all users
Contact information
University/Institution hosted University of Edinburgh
Address Edinburgh, EH8 9XD, UK
City Edinburgh
Province/State
Country/Region United Kingdom
Contact name Jamie A. Davies
Contact email jamie.davies@ed.ac.uk
Data information
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Publications
  • The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. [PMID: 26464438]
    Christopher Southan, Joanna L Sharman, Helen E Benson, Elena Faccenda, Adam J Pawson, Stephen P H Alexander, O Peter Buneman, Anthony P Davenport, John C McGrath, John A Peters, Michael Spedding, William A Catterall, Doriano Fabbro, Jamie A Davies, null null

    The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

    Nucleic acids research 2016:44(D1)

    842 Citations (from Europe PMC, 2019-03-23)

Rank

  • All: 20
  • Category:
    • Health and medicine: 3
    • Interaction: 3

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Record metadata

  • Created on: 2016-01-17
    • ***ina@***c.cn [2019-03-06]
    • ***haiman.pervaiz@***.com [2018-12-28]
    • ***ina@***c.cn [2018-06-01]
    • ***ina@***c.cn [2018-05-29]
    • ***ina@***c.cn [2016-04-08]
    • ***lin@***c.cn [2016-03-26]
    • ***lin@***c.cn [2016-01-27]
    • ***lin@***c.cn [2016-01-17]

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