GtoPdb Edit

Citations: 845

z-index: 281.67

Basic information
Short name GtoPdb
Description The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome.
Year founded 2015
Last update & version 2018-5-9 v2018.2
Availability Free to all users
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution University of Edinburgh
Address Edinburgh, EH8 9XD, UK
City Edinburgh
Country/Region United Kingdom
Contact name (PI/Team) Jamie A. Davies
Contact email (PI/Helpdesk)
Data information
Data object
Data type
Database category
Major organism
  • The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. [PMID: 26464438]
    Christopher Southan, Joanna L Sharman, Helen E Benson, Elena Faccenda, Adam J Pawson, Stephen P H Alexander, O Peter Buneman, Anthony P Davenport, John C McGrath, John A Peters, Michael Spedding, William A Catterall, Doriano Fabbro, Jamie A Davies, null null

    The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

    Nucleic Acids Res 2016:44(D1)

    845 Citations (from Europe PMC, 2019-05-18)


  • Ranking in all databases: No. 20
  • Ranking in category/categories:
    • Health and medicine: No. 3
    • Interaction: No. 3
The box plots depict Z-index distribution for all databases in Database Commons and for specific database category/categories. The red line indicates log2(Z-index) of GtoPdb.

Word cloud

Related Database



Record metadata

  • Created on: 2016-01-17
    • ***ina@*** [2019-03-06]
    • ***haiman.pervaiz@***.com [2018-12-28]
    • ***ina@*** [2018-06-01]
    • ***ina@*** [2018-05-29]
    • ***ina@*** [2016-04-08]
    • ***lin@*** [2016-03-26]
    • ***lin@*** [2016-01-27]
    • ***lin@*** [2016-01-17]

Community reviews 0 stars (0 reviews)

quality & quantity
organization & presentation
accessibility & reliability
Reviewed by