Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

miRNASNP (microRNA-related Single Nucleotide Polymorphisms)

General information

Description: miRNASNP aims to provide a resource of the miRNA-related SNPs, which includes SNPs in pre-miRNAs of human and other species, and target gain and loss by SNPs in miRNA seed regions or 3'UTR of target mRNAs.
Year founded: 2011
Last update: 2015-02-05
Version: v2.0
Accessibility:
Manual:
Accessible
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Country/Region: China
Data type:
RNA
Data object:
Database category:
Major organism:
Keywords:

Contact information

University/Institution: Huazhong University of Science and Technology
Address: Wuhan 430074 P.R. China
City: Wuhan
Province/State: Hubei
Country/Region: China
Contact name (PI/Team): An-Yuan Guo
Contact email (PI/Helpdesk): guoay@mail.hust.edu.cn

Record metadata

Created on: 2016-01-13
Curated by:
Lina Ma [2018-06-01]
Lin Liu [2016-03-30]

Ranking

All databases:
256/4549 (94.394%)
Genotype phenotype and variation:
31/611 (95.09%)
256
Total Rank
222
Citations
27.75
z-index

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Publications

25877638
An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. [PMID: 25877638]
Gong J, Liu C, Liu W, Wu Y, Ma Z, Chen H, Guo AY.

MicroRNAs (miRNAs) are key regulators of gene expression involved in a broad range of biological processes. MiRNASNP aims to provide single nucleotide polymorphisms (SNPs) in miRNAs and genes that may impact miRNA biogenesis and/or miRNA target binding. Advanced miRNA research provided abundant data about miRNA expression, validated targets and related phenotypic variants. In miRNASNP v2.0, we have updated our previous database with several new data and features, including: (i) expression level and expression correlation of miRNAs and target genes in different tissues, (ii) linking SNPs to the results of genome-wide association studies, (iii) integrating experimentally validated miRNA:mRNA interactions, (iv) adding multiple filters to prioritize functional SNPs. In addition, as a supplement of the database, we have set up three flexible online tools to analyse the influence of novel variants on miRNA:mRNA binding. A new nice web interface was designed for miRNASNP v2.0 allowing users to browse, search and download. We aim to maintain the miRNASNP as a solid resource for function, genetics and disease studies of miRNA-related SNPs. Database URL: http://bioinfo.life. hust.edu.cn/miRNASNP2/ © The Author(s) 2015. Published by Oxford University Press.

Database (Oxford). 2015:2015() | 35 Citations (from Europe PMC, 2020-02-15)
22045659
Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. [PMID: 22045659]
Gong J, Tong Y, Zhang HM, Wang K, Hu T, Shan G, Sun J, Guo AY.

MicroRNAs (miRNAs) are studied as key regulators of gene expression involved in different diseases. Several single nucleotide polymorphisms (SNPs) in miRNA genes or target sites (miRNA-related SNPs) have been proved to be associated with human diseases by affecting the miRNA-mediated regulatory function. To systematically analyze miRNA-related SNPs and their effects, we performed a genome-wide scan for SNPs in human pre-miRNAs, miRNA flanking regions, target sites, and designed a pipeline to predict the effects of them on miRNA-target interaction. As a result, we identified 48 SNPs in human miRNA seed regions and thousands of SNPs in 3' untranslated regions with the potential to either disturb or create miRNA-target interactions. Furthermore, we experimentally confirmed seven loss-of-function SNPs and one gain-of-function SNP by luciferase assay. This is the first case of experimental validation of an SNP in an miRNA creating a novel miRNA target binding. All useful data were complied into miRNASNP, a user-friendly free online database (http://www.bioguo.org/miRNASNP/). These data will be a useful resource for studying miRNA function, identifying disease-associated miRNAs, and further personalized medicine. © 2011 Wiley Periodicals, Inc.

Hum Mutat. 2012:33(1) | 187 Citations (from Europe PMC, 2020-02-15)