Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

Full name: Classification of Human Transcription Factors and Mammalian Orthologs
Description: TFClass is a classification of human transcription factors (TFs) and their mammalian orthologs based on the characteristics of their DNA-binding domains.
Year founded: 2012
Last update: 2017-10-26
Version: v3.0
Real time : Checking...
Country/Region: Germany
Data type:
Data object:
Database category:
Major organism:

Contact information

University/Institution: Georg August University
Address: Goldschmidtstr. 1, 37077 Göttingen, Germany
City: Göttingen
Country/Region: Germany
Contact name (PI/Team): Edgar Wingender
Contact email (PI/Helpdesk):


TFClass: expanding the classification of human transcription factors to their mammalian orthologs. [PMID: 29087517]
Wingender E, Schoeps T, Haubrock M, Krull M, Dönitz J.

TFClass is a resource that classifies eukaryotic transcription factors (TFs) according to their DNA-binding domains (DBDs), available online at The classification scheme of TFClass was originally derived for human TFs and is expanded here to the whole taxonomic class of mammalia. Combining information from different resources, checking manually the retrieved mammalian TFs sequences and applying extensive phylogenetic analyses, >39 000 TFs from up to 41 mammalian species were assigned to the Superclasses, Classes, Families and Subfamilies of TFClass. As a result, TFClass now provides the corresponding sequence collection in FASTA format, sequence logos and phylogenetic trees at different classification levels, predicted TF binding sites for human, mouse, dog and cow genomes as well as links to several external databases. In particular, all those TFs that are also documented in the TRANSFAC® database (FACTOR table) have been linked and can be freely accessed. TRANSFAC® FACTOR can also be queried through an own search interface.

Nucleic Acids Res. 2018:46(D1) | 19 Citations (from Europe PMC, 2021-01-16)
TFClass: a classification of human transcription factors and their rodent orthologs. [PMID: 25361979]
Wingender E, Schoeps T, Haubrock M, Dönitz J.

TFClass aims at classifying eukaryotic transcription factors (TFs) according to their DNA-binding domains (DBDs). For this, a classification schema comprising four generic levels (superclass, class, family and subfamily) was defined that could accommodate all known DNA-binding human TFs. They were assigned to their (sub-)families as instances at two different levels, the corresponding TF genes and individual gene products (protein isoforms). In the present version, all mouse and rat orthologs have been linked to the human TFs, and the mouse orthologs have been arranged in an independent ontology. Many TFs were assigned with typical DNA-binding patterns and positional weight matrices derived from high-throughput in-vitro binding studies. Predicted TF binding sites from human gene upstream sequences are now also attached to each human TF whenever a PWM was available for this factor or one of his paralogs. TFClass is freely available at through a web interface and for download in OBO format. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Nucleic Acids Res. 2015:43(Database issue) | 36 Citations (from Europe PMC, 2021-01-16)
TFClass: an expandable hierarchical classification of human transcription factors. [PMID: 23180794]
Wingender E, Schoeps T, Dönitz J.

TFClass ( provides a comprehensive classification of human transcription factors based on their DNA-binding domains. Transcription factors constitute a large functional family of proteins directly regulating the activity of genes. Most of them are sequence-specific DNA-binding proteins, thus reading out the information encoded in cis-regulatory DNA elements of promoters, enhancers and other regulatory regions of a genome. TFClass is a database that classifies human transcription factors by a six-level classification schema, four of which are abstractions according to different criteria, while the fifth level represents TF genes and the sixth individual gene products. Altogether, nine superclasses have been identified, comprising 40 classes and 111 families. Counted by genes, 1558 human TFs have been classified so far or >2900 different TFs when including their isoforms generated by alternative splicing or protein processing events. With this classification, we hope to provide a basis for deciphering protein-DNA recognition codes; moreover, it can be used for constructing expanded transcriptional networks by inferring additional TF-target gene relations.

Nucleic Acids Res. 2013:41(Database issue) | 68 Citations (from Europe PMC, 2021-01-16)


All databases:
474/4728 (89.996%)
Gene genome and annotation:
183/1297 (85.968%)
66/865 (92.486%)
45/658 (93.313%)
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Record metadata

Created on: 2015-06-20
Curated by:
Dong Zou [2019-03-23]
hadia abbasi [2018-08-15]
Dong Zou [2018-03-05]
Lina Ma [2016-09-26]
Zhang Zhang [2016-05-08]
Guangyu Wang [2016-04-01]
Guangyu Wang [2015-11-24]
Guangyu Wang [2015-06-26]