| Accession | PRJCA000524 |
|---|---|
| Title | Human brain evolution |
| Umbrella project |
eGPS: evolutionary Genotype-Phenotype Systems biology Cranial Capacity & Structure Genetic mechanism and function of key genes in the evolution of animal brain |
| Data types |
Phenotype or Genotype
Transcriptome or Gene expression Raw sequence reads |
| Organisms | Macaca mulatta |
| Description | We report the application of RNA sequencing technology for high-throughput profiling of RNA expression in monkey tissues. By obtaining over four billion bases of sequence of brain, liver and muscle from MCPH1 transgenic monkey and two control monkeys. We find that brain tissue showed more differentially expressed genes compared with those in liver and muscle. Finally, we show that This result implies that the over expressed huMCPH1 may have a global impact on multiple organs of the transgenic monkey, and it has the largest impact on the brain in terms of gene numbers. |
| Sample scope | RNA |
| Release date | 2020-07-10 |
| Submitter | Lei Shi (leshi@med.umich.edu) |
| Organization | Kunming Institute of Zoology(KIZ) |
| Submission date | 2017-08-17 |
| Resource name (Count) | File Size (MB) |
| BioSample (63) | - |
| GSA (1) | - |
| CRA000343 | 303,514.25 |