| Accession | PRJCA014400 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Title | Re-sequenced high-quality 1k pig genomes enable accurate haplotypes construction and robust selection signature detection | ||||||||||||
| Relevance | Agricultural | ||||||||||||
| Data types | Variation | ||||||||||||
| Organisms | Sus scrofa | ||||||||||||
| Description | High-quality whole-genome resequencing in large-scale pig populations with pedigree structure and multiple breeds would enable accurate construction of haplotype and robust selection-signature detection. Here, we sequenced 889 pigs, retrieved 207 resequencing data, and formed a panel of worldwide distributed wild boars, aboriginal and highly selected pigs with pedigree structures amount to 1,096 genomes from 43 breeds. Combining with their haplotype-informative reads and pedigree structure, we accurately constructed a panel of 1,874 haploid genomes with 41,964,356 genetic variants. We further demonstrated its valuable applications in GWAS by identifying five novel loci for intramuscular fat content, and in genome selection by increasing the accuracy of estimated breeding value by 36.7%. In evolutionary selection, we detected MUC13 gene under a long-term balancing selection, as well as NPR3 gene under positive selection for pig stature. Our study provides abundant genomic variations for robust selection-signature detection and accurate haplotypes for deciphering complex traits in pigs. | ||||||||||||
| Sample scope | Multiisolate | ||||||||||||
| Release date | 2023-01-13 | ||||||||||||
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| Submitter | Tong Xinkai (xinkaitong@hotmail.com) | ||||||||||||
| Organization | Jiangxi Agricultural University | ||||||||||||
| Submission date | 2023-01-12 |
| Resource name | Description |
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| BioSample (937) show | - |