| Accession | PRJCA013456 | ||||||||||||||||||||||||
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| Title | Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV to mammals | ||||||||||||||||||||||||
| Relevance | Model organism | ||||||||||||||||||||||||
| Data types |
Transcriptome or Gene expression
Raw sequence reads |
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| Organisms |
Atelerix albiventris
Callosciurus erythraeus Chaerephon plicatus Nyctereutes procyonoides Tylonycteris robustula Neovison vison Eonycteris spelaea Petaurus breviceps Pteropus alecto Oryctolagus cuniculus Murina leucogaster Pipistrellus javanicus Myotis siligorensis Paguma larvata Cavia porcellus Myotis ricketti Aselliscus stoliczkanus Rhinolophus malayanus Monodelphis domestica Mustela putorius Vulpes vulpes Hipposideros pomona Procavia capensis Myotis fimbriatus Rhinolophus ferrumequinum Bos taurus Myotis laniger Plecotus auritus Rhinolophus rex Graphiurus kelleni Pipistrellus abramus Myotis muricola Myotis chinensis Heterocephalus glaber Miniopterus fuliginosus |
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| Description | Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first performed on 83 cell cultures derived from 55 mammalian species using pseudotyped viruses bearing S proteins from SARS-CoV-2, SARS-CoV, and MERS-CoV. Cell cultures from Thomas's horseshoe bat, king horseshoe bat, green monkey, and ferret were found to be highly susceptible to SARS-CoV-2, SARS-CoV, and MERS-CoV pseudotyped viruses. Moreover, five variants (del69-70, D80Y, S98F, T572I, and Q675H) that beside spike receptor-binding domain can significantly alter the host tropism of SARS-CoV-2. An examination of phylogenetic signals of transduction rates revealed that closely related taxa generally have similar susceptibility to MERS-CoV but not to SARS-CoV and SARS-CoV-2 pseudotyped viruses. Additionally, we discovered the expression of entry receptors, i.e., ACE2 and DPP4, shown poor correlation with susceptibility to infection across mammalian taxa. This study provides a basic documentation of likely susceptibility, variants, and molecules that underline the cross-species transmission of these coronaviruses. | ||||||||||||||||||||||||
| Sample scope | Multispecies | ||||||||||||||||||||||||
| Release date | 2023-06-12 | ||||||||||||||||||||||||
| Publication |
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| Grants |
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| Submitter | Xuming Zhou (zhouxuming@ioz.ac.cn) | ||||||||||||||||||||||||
| Organization | Institute of Zoology, Chinese Academy of Sciences | ||||||||||||||||||||||||
| Submission date | 2022-11-24 |