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Accession PRJCA005222
Title Hypertension susceptibility genes in Xinjiang Han population
Relevance Medical
Data types Targeted Locus (Loci)
Organisms Homo sapiens
Description Essential hypertension is a common cardiovascular disease with complex etiology, closely related to genetic and environmental factors. The pathogenesis of hypertension involves alteration in vascular resistance caused by sympathetic nervous system (SNS) and renin angiotensin system (RAS). Susceptibility factors of hypertension vary with regions and ethnicities.Due to its special geographical location, Xinjiang belongs to temperate continental arid climate, with huge differences in temperature throughout the year. Moreover, most cities in Xinjiang are at a high altitude, with relative low oxygen content, which have a special impact on development and progression of cardiovascular diseases. This research focuses on hypertensive patients who are Han nationality, born and living in Xinjiang, to discover genetic factors susceptible to hypertension due to different living environments. In this study, we conducted target capture sequencing on 54 genes related to SNS and RAS derived from a collection of Han nationality, consisting of 151 hypertension patients and 65 normal subjects in Xinjiang, China. To study hypertension susceptibility genes of Han Chinese in Xinjiang.
Sample scope Multiisolate
Release date 2021-05-21
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) Regional Science Foundation Project 81260057
Natural Science Foundation of Xinjiang Autonomous Region 2010211A33
Natural Science Foundation of Xinjiang Autonomous Region 2012211A033
Submitter xizi    wang  (wxizi0901@163.com)
Organization Liaocheng People's Hospital
Submission date 2021-05-21

Project Data

Resource name Description
BioSample (216)  show -