Accession PRJCA002851
Title Dynamic epigenomic landscapes during early lineage specification in mouse embryos
Relevance Model organism
Data types Whole genome sequencing
Organisms Mus musculus
Description In mammals, all somatic development originates from lineage segregation in early embryos. However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell fate commitment remains poorly characterized. Here we report a comprehensive investigation of transcriptomes and base-resolution methylomes for early lineages in peri- and postimplantation mouse embryos. We found allele-specific and lineage-specific de novo methylation at CG and CH sites that led to differential methylation between embryonic and extraembryonic lineages at promoters of lineage regulators, gene bodies, and DNA-methylation valleys. By using Hi-C experiments to define chromatin architecture across the same developmental period, we demonstrated that both global demethylation and remethylation in early development correlate with chromatin compartments. Dynamic local methylation was evident during gastrulation, which enabled the identification of putative regulatory elements. Finally, we found that de novo methylation patterning does not strictly require implantation. These data reveal dynamic transcriptomes, DNA methylomes, and 3D chromatin landscapes during the earliest stages of mammalian lineage specification.
Sample scope Multiisolate
Release date 2020-06-14
PubMed ID Article title Journal name DOI Year
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 2016YFC0900300
Submitter Yu    Zhang  (
Organization Tsinghua University
Submission date 2020-06-12

Project Data

Resource name Description
BioSample (65)  show -
GSA (1) -
CRA002788 Dynamic epigenomic landscapes during early lineage specification in mouse embryos