Accession PRJCA002797
Title Regulatory effect and mechanism of nuclear matrix-related long non-coding RNA on liver lipid metabolism and 3D genome
Relevance Medical
Data types Whole genome sequencing
Epigenomics
Transcriptome or Gene expression
Genome sequencing and assembly
Organisms Mus musculus
Description In eukaryotic cells, chromosomes are folded into higher-level structures at different levels to regulate genome function, but the molecular mechanism of their formation remains unclear. We hypothesized that nuclear matrix-related RNA plays a key regulatory role in the three-dimensional genome, and identified 54 nuclear matrix-related long noncoding RNAs (named NMALTs) from mouse livers. This project intends to continue to explore the in vivo function and mechanism of NMALT1 on the basis of previous research: 1) study the short-term and long-term effects on lipid metabolism through in vivo RNA interference and liver conditional knockout mice; Targets of action, regulatory networks, and effects on the three-dimensional structure of chromatin; 3) To explore the correlation between the expression and genetic variation of homologous genes and human metabolic syndrome. The research of this project may reveal new molecules and mechanism of action that regulate the three-dimensional genome structure, and may provide new targets for the analysis and diagnosis and treatment of human metabolic syndrome.
Sample scope Monoisolate
Release date 2020-06-04
Publication
PubMed ID Article title Journal name DOI Year
33285284 G9a/GLP-Sensitivity of H3K9me2 Demarcates Two Types of Genomic Compartments Genomics, Proteomics & Bioinformatics 10.1016/j.gpb.2020.08.001 2020
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) General Program 31771435
Submitter Zixiang    Yan  (yanzx1991@qq.com)
Organization Fudan University
Submission date 2020-06-04

Project Data

Resource name Description
BioSample (32)  show -
GSA (1) -
CRA002762 Effects of H3K9me2 on 3D genome organization