Accession | PRJCA002797 | ||||||||||
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Title | Regulatory effect and mechanism of nuclear matrix-related long non-coding RNA on liver lipid metabolism and 3D genome | ||||||||||
Relevance | Medical | ||||||||||
Data types |
Whole genome sequencing
Epigenomics Transcriptome or Gene expression Genome sequencing and assembly |
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Organisms | Mus musculus | ||||||||||
Description | In eukaryotic cells, chromosomes are folded into higher-level structures at different levels to regulate genome function, but the molecular mechanism of their formation remains unclear. We hypothesized that nuclear matrix-related RNA plays a key regulatory role in the three-dimensional genome, and identified 54 nuclear matrix-related long noncoding RNAs (named NMALTs) from mouse livers. This project intends to continue to explore the in vivo function and mechanism of NMALT1 on the basis of previous research: 1) study the short-term and long-term effects on lipid metabolism through in vivo RNA interference and liver conditional knockout mice; Targets of action, regulatory networks, and effects on the three-dimensional structure of chromatin; 3) To explore the correlation between the expression and genetic variation of homologous genes and human metabolic syndrome. The research of this project may reveal new molecules and mechanism of action that regulate the three-dimensional genome structure, and may provide new targets for the analysis and diagnosis and treatment of human metabolic syndrome. | ||||||||||
Sample scope | Monoisolate | ||||||||||
Release date | 2020-06-04 | ||||||||||
Publication |
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Grants |
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Submitter | Zixiang Yan (yanzx1991@qq.com) | ||||||||||
Organization | Fudan University | ||||||||||
Submission date | 2020-06-04 |