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Accession PRJCA002760
Title Whole Genome Sequencing in Esophageal Squamous Cell Carcinoma
Relevance Medical
Data types Whole genome sequencing
Organisms Homo sapiens
Description In this project, we performed deep WGS in microneedle-punctured formalin fixed paraffin embedded tumor tissues and matched adjacent noncancerous specimens on a large set of ESCC patients with clinical follow up data. Herein, we classify ESCC into three main subtypes based on clinically relevant genomic alterations and implicate the association of these subtypes with outcomes of patients. Our genomic study uncovers an extensive landscape of driver genetic alterations across coding and noncoding regions, and defines their potential molecular pathology in ESCC.
Sample scope Monoisolate
Release date 2020-05-29
Publication
PubMed ID Article title Journal name DOI Year
32398863 Whole-genome Sequencing of 508 Patients Identifies Key Molecular Features Associated With Poor Prognosis in Esophageal Squamous Cell Carcinoma Cell Research 10.1038/s41422-020-0333-6 2020
32341351 Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma Cell Death & Disease 10.1038/s41419-020-2492-2 2020
35396552 Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma Cell Death Discovery 10.1038/s41420-022-00984-9 2022
35654793 Comprehensive characterization of posttranscriptional impairment-related 3'-UTR mutations in 2413 whole genomes of cancer patients NPJ Genomic Medicine 10.1038/s41525-022-00305-0 2022
36272974 Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma Nature Communications 10.1038/s41467-022-33994-3 2022
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2016YFC1302100
Chinese Academy of Sciences (CAS) 2016I2M1001
Chinese Academy of Sciences (CAS) 2019I2M1003
National Natural Science Foundation of China (NSFC) 81490753
National Natural Science Foundation of China (NSFC) 81330063
National Natural Science Foundation of China (NSFC) 11971039
Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Sanming Project of Medicine in Shenzhen SZSM201812088
Department of science and technology of Guangdong Province the Guangdong Basic and Applied Basic Research Foundation 2019B030302012
Submitter Zhihua    Liu  (liuzh@cicams.ac.cn)
Organization National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Submission date 2020-05-29

Project Data

Resource name Description
BioSample (1016)  show -