Accession PRJCA002739
Title The influence of immune heterogeneity on the effectiveness of immune checkpoint inhibitors in multifocal hepatocellular carcinomas
Relevance Medical
Data types Transcriptome or Gene expression
Organisms Homo sapiens
Description Immunotherapy is emerging as a promising strategy in hepatocellular carcinoma (HCC), but its low response rate and mixed responses among different nodules remained to be a major challenge. In this study, we deciphered genomic and immune characteristics among tumors with different sizes in multifocal HCC patients through whole genome sequencing and RNA sequencing. We found the small and large nodules within the same patient presented with similar genomic characteristics, indicating that the small and large nodules were intrahepatic metastasis. Further analysis revealed that the small tumors had higher immune cell infiltration and upregulation of immune pathways as compared to the large tumor of the same multifocal HCC case, which may partially explain the different responses of small and large tumors to anti-PD-1 treatment.
Sample scope Multiisolate
Release date 2020-09-30
Publication
PubMed ID Article title Journal name DOI Year
32527942 The influence of immune heterogeneity on the effectiveness of immune checkpoint inhibitors in multifocal hepatocellular carcinomas Clinical Cancer Research 10.1158/1078-0432.CCR-19-3840 2020
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 81825013
National Natural Science Foundation of China (NSFC) 81771958
Submitter Sui    Peng  (pengsui@vip.163.com)
Organization The First Affiliated Hospital, Sun Yat-sen University
Submission date 2020-05-25

Project Data

Resource name Description
BioSample (18)  show -