Accession PRJCA002011
Title Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma
Relevance Medical
Data types Epigenomics
Organisms Homo sapiens
Description To investigate the mechanisms and pathways enabling resistance to BRAFi in melanomas, we integrated expression data, ATAC-seq, and CRISPR screen results. Our findings reveal genes whose loss of function conferred resistance to a selective BRAF inhibitor, providing new insight into signaling pathways that contribute to acquired resistance in melanoma.
Sample scope Monoisolate
Release date 2019-12-09
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 81872290
National Natural Science Foundation of China (NSFC) 31801185
Submitter Binbin    Wang  (1610790@tongji.edu.cn)
Organization Tongji University
Submission date 2019-12-09

Project Data

Resource name Description
BioSample (4) -
SAMC122137 ATAC-seq of M238R1: PLX4720
SAMC122136 ATAC-seq of M238R1: DMSO
SAMC122135 ATAC-seq of M238: PLX4720
SAMC122134 ATAC-seq of M238: DMSO
GSA (1) -
CRA002184 Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma