Accession |
PRJCA001786 |
Title |
Central Role of RNA m6A Methyltransferase Mettl3 in Liver Metabolic Disorders and Hepatogenous diabetes |
Relevance |
Model organism |
Data types |
Raw sequence reads
|
Organisms |
Mus musculus
|
Description |
We show that both Mettl3 expression and m6A level increased in the liver of mice with High Fat Diet (HFD)-induced metabolic disorders, and overexpression of Mettl3 aggravated HFD-induced liver metabolic disorders and insulin resistance. Hepatocyte-specific knockout of Mettl3 significantly alleviated HFD-induced metabolic disorders by slowing weight gain, reducing lipid accumulation and improving insulin sensitivity. |
Sample scope |
Multiisolate |
Release date |
2020-11-13 |
Publication |
PubMed ID |
Article title |
Journal name |
DOI |
Year |
33160098
|
m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes
|
Genomics, Proteomics & Bioinformatics
|
10.1016/j.gpb.2020.06.003
|
2020
|
|
Grants |
Agency |
program |
Grant ID |
Grant title |
Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
NA
|
|
|
Submitter |
sun
baofa (sunbf@big.ac.cn)
|
Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
Submission date |
2019-09-27 |