Accession PRJCA001786
Title Central Role of RNA m6A Methyltransferase Mettl3 in Liver Metabolic Disorders and Hepatogenous diabetes
Relevance Model organism
Data types Raw sequence reads
Organisms Mus musculus
Description We show that both Mettl3 expression and m6A level increased in the liver of mice with High Fat Diet (HFD)-induced metabolic disorders, and overexpression of Mettl3 aggravated HFD-induced liver metabolic disorders and insulin resistance. Hepatocyte-specific knockout of Mettl3 significantly alleviated HFD-induced metabolic disorders by slowing weight gain, reducing lipid accumulation and improving insulin sensitivity.
Sample scope Multiisolate
Release date 2020-11-13
Grants
Agency program Grant ID Grant title
Chinese Academy of Sciences (CAS) Strategic Priority Research Program of Chinese Academy of Sciences (CAS) NA
Submitter sun    baofa  (sunbf@big.ac.cn)
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2019-09-27

Project Data

Resource name Description
BioSample (12)  show -
GSA (1) -
CRA002000 m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes