| Accession |
PRJCA001632 |
| Title |
Efficient gene correction of an aberrant splice site in β-Thalassemia iPSCs |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
In this study, according to two different strategies, the HBB IVS2-654 mutation was seamlessly corrected in iPSCs by CRISPR/Cas9 system and ssODN. To reduce the occurrence of secondary cleavage, a more efficient strategy was adopted. |
| Sample scope |
Multiisolate |
| Release date |
2019-09-20 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 31631510
|
Efficient gene correction of an aberrant splice site in β-thalassaemia iPSCs by CRISPR/Cas9 and single-strand oligodeoxynucleotides
|
Journal of Cellular and Molecular Medicine
|
10.1111/jcmm.14669
|
2019
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Natural Science Foundation of Guangdong Province
|
|
2014A030312012
|
|
|
|
| Submitter |
Zeyu
Xiong (zeyu_xiong@163.com)
|
| Organization |
The Third Affiliated Hospital of Guangzhou Medical University |
| Submission date |
2019-08-05 |
