Accession PRJCA001632
Title Efficient gene correction of an aberrant splice site in β-Thalassemia iPSCs
Relevance Medical
Data Types Whole genome sequencing
Organisms Homo sapiens
Description In this study, according to two different strategies, the HBB IVS2-654 mutation was seamlessly corrected in iPSCs by CRISPR/Cas9 system and ssODN. To reduce the occurrence of secondary cleavage, a more efficient strategy was adopted.
Sample scope Multiisolate
Release date 2019-09-20
Grants
Agency program Grant ID Grant title
Natural Science Foundation of Guangdong Province 2014A030312012
Submitter Zeyu    Xiong  (zeyu_xiong@163.com)
Organization The Third Affiliated Hospital of Guangzhou Medical University
Submission date 2019-08-05

Project Data

Resource name Description
BioSample (4) -
SAMC089109 Corrected C2-iPS
SAMC089108 Corrected C1-iPS
SAMC089107 M-iPS
SAMC089106 Pre-iPS
GSA (1) -
CRA001893 The whole exome sequencing data of cell lines before or after gene correction of the HBB IVS2-654 mutation
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