Accession | PRJCA001337 | ||||||||||||||||||||
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Title | Alterations of the human gut microbiota in unraptured intracranial aneurysms | ||||||||||||||||||||
Relevance | Medical | ||||||||||||||||||||
Data types |
Metagenome
Transcriptome or Gene expression |
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Organisms |
mouse gut metagenome
Mus musculus human gut metagenome |
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Description | Unruptured intracranial aneurysms (UIAs) are life-threatening cerebrovascular diseases driven by chronic inflammation. In recent years, significant interest has focused on gut microbiota host interaction because accumulating evidence has revealed that gut microbiota plays a pivotal role in multiple disease. However, whether gut microbiota dysbiosis participates in the development of UIAs remains largely unknown. We performed a metagenome-wide association study in a cohort of 100 UIAs and 100 controls, Chinese individuals. A cohort of 40 UIAs individuals and 40 controls was studied for further validation. Fecal microbiota transplantation from patients to C57BL/6N mice which were pre-treated with antibiotics was conducted to evaluate the role of gut microbiota in contributing to the pathogenesis of UIAs. | ||||||||||||||||||||
Sample scope | Multiisolate | ||||||||||||||||||||
Release date | 2020-04-23 | ||||||||||||||||||||
Publication |
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Grants |
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Submitter | Li Hao (lihao@bjmu.edu.cn) | ||||||||||||||||||||
Organization | Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College | ||||||||||||||||||||
Submission date | 2019-03-20 |