Accession PRJCA001079
Title SSATX, an alternative splicing of sat1, functions as a tumor suppressor in human melanoma cells through RNA-SEQ analysis via regulating Wnt signaling
Data Types Transcriptome or Gene expression
Organisms Homo sapiens
Description Human sat1 gene produces two transcript varients, one translates Spermidine/spermine N-1 acetyltransferase (SSAT1), the rate limiting enzyme in the catabolism of polyamines; the other is SSATX, however, its biological functions remain largely unknown. We found that SSATX knockdown remarkably promoted the proliferation, migration and invasion of human melanoma cells. To gain insights into the mechanism of SSATX-mediated tumor cell proliferation, migration and invasion, we performed RNA-seq analysis of A2058-scramble and A2058-shSSATX cells. Our results revealed that repression of SSATX activated Wnt signaling pathways.
Sample scope Monoisolate
Release date 2018-10-18
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 81672698 31471236
Submitter Qiong    Yang  (yangqiong@big.ac.cn)
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2018-10-18

Project Data

Resource name Description
BioSample (2) -
SAMC047298 A2058-scramble
SAMC047299 A2058-shSSATX
GSA (1) -
CRA001180 mRNA profiles of SSATX knockdown (KD) in A2058 cell line were generated using Ion torrent
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