Accession PRJCA001040
Title Pathogenesis of phytopathogenic bacteria
Data Types Raw sequence reads
Organisms Xanthomonas campestris pv. campestris
Description we aimed to identifythe physiological substrates of Prc and investigate the role of Prc-catalysed proteolysis in controlling the environmental adaptation of X. campestris pv. campestris, which is more genetically amenable than X. oryzae pv. oryzae. Under osmostress, Prc directly bound and cleaved the sensor region of VgrS, a canonical histidine kinase (HK) controlling bacterial virulence and stress responses. Proteolysis of the VgrS sensor resulted in the inhibition of the autokinase activity of this HK, which caused a reprogramming of VgrS-triggered gene expressions and significantly promoted bacterial resistance to osmostress. Because Prc-like proteases and HKs are signaling proteins commonly distributed in the kingdom of Gram-negative bacteria, the inactivation of HK by periplasmic protease may be a general and important form of cross-talk between two-component signalling systems (TCSs) and proteolysis regulation.
Sample scope Monoisolate
Release date 2018-09-19
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) Grant Nos 31671989
Chinese Academy of Sciences (CAS) Grant No XDB11040700
National Natural Science Foundation of China (NSFC) Grant Nos 31600062
National Natural Science Foundation of China (NSFC) Grant Nos 31370127
Ministry of Science and Technology of the People's Republic of China (MOST) Grant No 2011CB100700
Submitter Huan    Zhang  (
Organization Beijing Institute of Microbiology of Chinese Academy of Sciences
Submission date 2018-09-19

Project Data

Resource name Description
BioSample (2) -
SAMC046141 DLT_Prc CvgrR-His6
SAMC046136 ChIP-seq raw data
GSA (1) -
CRA001122 Xcc 8004