Accession PRJCA001008
Title m6A enhances long-term memory formation
Relevance Model organism
Data Types Transcriptome or Gene expression
Raw sequence reads
Organisms Mus musculus
Description The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through promoting the translation of neuronal early-response genes. Such effect is exquisitely dependent on the m6A methyltransferase function of METTL3. Depleting METTL3 in mouse hippocampus reduces memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m6A methyltransferase function of METTL3 was restored. The abundance of METTL3 in wild-type mouse hippocampus is positively correlated with learning efficacy, and overexpression of METTL3 significantly enhances long-term memory consolidation. These findings uncover a direct role of RNA m6A modification in regulating long-term memory formation, and also indicate that memory efficacy difference among individuals could be compensated by repeated learning.
Sample scope Monoisolate
Release date 2018-10-11
PubMed ID Article title Journal name DOI Year
30297870 METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation Cell Research 10.1038/s41422-018-0092-9 2018
Agency program Grant ID Grant title
Chinese Academy of Sciences (CAS) XDA16020801
National Natural Science Foundation of China (NSFC) 91540204
Ministry of Science and Technology of the People's Republic of China (MOST) 2014CB964901
Chinese Academy of Sciences (CAS) QYZDJ SSW SMC015
National Natural Science Foundation of China (NSFC) 31625016
Chinese Academy of Sciences (CAS) QYZDY SSW SMC027
Submitter Xiu-Jie    Wang  (
Organization Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Submission date 2018-08-28

Project Data

Resource name Description
BioSample (20) -
SAMC045513 m6A_S4h
SAMC045512 m6A_S1h
SAMC045511 m6A_S30m
SAMC045510 m6A_naive
SAMC045509 16_4h-CTRL
SAMC045508 15_4h-CTRL
SAMC045507 14_4h-KO
SAMC045506 13_4h-KO
SAMC045505 12_1h-CTRL
SAMC045504 11_1h-CTRL
SAMC045503 10_1h-KO
SAMC045502 9_1h-KO
SAMC045501 8_naive-CTRL
SAMC045500 7_naive-CTRL
SAMC045499 6_naive-KO
SAMC045498 5_naive-KO
SAMC045497 4_30m-CTRL
SAMC045496 3_30m-CTRL
SAMC045495 2_30m-KO
SAMC045494 1_30m-KO
GSA (1) -
CRA001077 m6A enhances long-term memory formation