Accession PRJCA001008
Title m6A enhances long-term memory formation
Relevance Model organism
Data types Transcriptome or Gene expression
Raw sequence reads
Organisms Mus musculus
Description The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through promoting the translation of neuronal early-response genes. Such effect is exquisitely dependent on the m6A methyltransferase function of METTL3. Depleting METTL3 in mouse hippocampus reduces memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m6A methyltransferase function of METTL3 was restored. The abundance of METTL3 in wild-type mouse hippocampus is positively correlated with learning efficacy, and overexpression of METTL3 significantly enhances long-term memory consolidation. These findings uncover a direct role of RNA m6A modification in regulating long-term memory formation, and also indicate that memory efficacy difference among individuals could be compensated by repeated learning.
Sample scope Monoisolate
Release date 2018-10-11
Publication
PubMed ID Article title Journal name DOI Year
30297870 METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation Cell Research 10.1038/s41422-018-0092-9 2018
Grants
Agency program Grant ID Grant title
Chinese Academy of Sciences (CAS) XDA16020801
National Natural Science Foundation of China (NSFC) 91540204
Ministry of Science and Technology of the People's Republic of China (MOST) 2014CB964901
Chinese Academy of Sciences (CAS) QYZDJ SSW SMC015
National Natural Science Foundation of China (NSFC) 31625016
Chinese Academy of Sciences (CAS) QYZDY SSW SMC027
Submitter Xiu-Jie    Wang  (xjwang@genetics.ac.cn)
Organization Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Submission date 2018-08-28

Project Data

Resource name Description
BioSample (20)  show -
GSA (1) -
CRA001077 m6A enhances long-term memory formation