Accession |
PRJCA001008 |
Title |
m6A enhances long-term memory formation |
Relevance |
Model organism |
Data types |
Transcriptome or Gene expression
Raw sequence reads
|
Organisms |
Mus musculus
|
Description |
The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through promoting the translation of neuronal early-response genes. Such effect is exquisitely dependent on the m6A methyltransferase function of METTL3. Depleting METTL3 in mouse hippocampus reduces memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m6A methyltransferase function of METTL3 was restored. The abundance of METTL3 in wild-type mouse hippocampus is positively correlated with learning efficacy, and overexpression of METTL3 significantly enhances long-term memory consolidation. These findings uncover a direct role of RNA m6A modification in regulating long-term memory formation, and also indicate that memory efficacy difference among individuals could be compensated by repeated learning. |
Sample scope |
Monoisolate |
Release date |
2018-10-11 |
Publication |
PubMed ID |
Article title |
Journal name |
DOI |
Year |
30297870
|
METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation
|
Cell Research
|
10.1038/s41422-018-0092-9
|
2018
|
|
Grants |
Agency |
program |
Grant ID |
Grant title |
Chinese Academy of Sciences (CAS)
|
|
XDA16020801
|
|
National Natural Science Foundation of China (NSFC)
|
|
91540204
|
|
Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2014CB964901
|
|
Chinese Academy of Sciences (CAS)
|
|
QYZDJ SSW SMC015
|
|
National Natural Science Foundation of China (NSFC)
|
|
31625016
|
|
Chinese Academy of Sciences (CAS)
|
|
QYZDY SSW SMC027
|
|
|
Submitter |
Xiu-Jie
Wang (xjwang@genetics.ac.cn)
|
Organization |
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences |
Submission date |
2018-08-28 |