| Accession |
PRJCA000975 |
| Title |
m5C hypermethylation promotes the pathogenesis of urothelial carcinoma of the bladder |
| Relevance |
Medical |
| Data types |
Epigenomics
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
RNA modifications, especially N6-methyladenosine (m6A), have been proven to participate in diverse cellular functions and process. 5-methylcytosine (m5C) is another important RNA modification, however, both its distribution and regulatory role in pathological conditions (such as cancers) remain unknown. Herein, we provide the first landscapes of m5C modification at single-nucleotide resolution on mRNAs from human urothelial carcinoma of the bladder (UCB). We identified multiple m5C hypermethylation sites on numerous upregulated mRNAs of proto-oncogenes in UCB tissues. |
| Sample scope |
Monoisolate |
| Release date |
2023-03-10 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 31358969
|
5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs
|
Nature Cell Biology
|
10.1038/s41556-019-0361-y
|
2019
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2016YFC0900300
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31430022
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31625016
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0109700
|
|
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDA16010501
|
|
|
|
| Submitter |
sun
baofa (sunbf@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2018-07-31 |
