Accession PRJCA000975
Title m5C hypermethylation promotes the pathogenesis of urothelial carcinoma of the bladder
Relevance Medical
Data types Epigenomics
Transcriptome or Gene expression
Organisms Homo sapiens
Description RNA modifications, especially N6-methyladenosine (m6A), have been proven to participate in diverse cellular functions and process. 5-methylcytosine (m5C) is another important RNA modification, however, both its distribution and regulatory role in pathological conditions (such as cancers) remain unknown. Herein, we provide the first landscapes of m5C modification at single-nucleotide resolution on mRNAs from human urothelial carcinoma of the bladder (UCB). We identified multiple m5C hypermethylation sites on numerous upregulated mRNAs of proto-oncogenes in UCB tissues.
Sample scope Monoisolate
Release date 2019-06-11
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) 2016YFC0900300
National Natural Science Foundation of China (NSFC) 31430022
National Natural Science Foundation of China (NSFC) 31625016
Submitter sun    baofa  (sunbf@big.ac.cn)
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2018-07-31

Project Data

Resource name Description
BioSample (145)  show -
GSA (1) -
CRA001050 m5C hypermethylation promotes the pathogenesis of urothelial carcinoma of the bladder