Accession PRJCA000860
Title Genome-wide parent-of-origin DNA methylation analysis [Methyl-seq]
Relevance Medical
Data types Epigenomics
Organisms Homo sapiens
Description Genomic imprinting is a form of epigenetic regulation that results in expression of either the maternally or paternally inherited allele of a subset of genes. Imprinted loci contain differentially methylated regions (DMRs) where cytosine methylation marks one of the parental alleles, providing cis-acting regulatory elements that influence the allelic expression of surrounding genes, however to date the total number of imprinted loci within the human genome is unknown. To characterize known imprinted DMRS and identify novel imprinted loci we have performed whole-genome bisulphite sequencing and high-resolution DNA methylation array analysis of healthy tissues. Overall design: Sequencing of bisulfite converted DNA analysis of normal brain (white matter), liver and term placenta tissue.
Sample scope Multiisolate
Release date 2018-05-30
Publication
PubMed ID Article title Journal name DOI Year
24402520
Accessions in other database
Accession Database name
PRJNA201856 NCBI
Submitter Fang    Liang  (liangf@big.ac.cn)
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2018-04-28

Project Data

Resource name Description
BioSample (2) -
SAMC047330 Healthy normal placenta tissue
SAMC047301 normal liver tissue