Accession PRJCA000857
Title Nuclear PTEN safeguards pre-mRNA splicing to link Golgi extension and secretion for its tumor suppressive role
Data type Raw sequence reads
Organism Homo sapiens
Description Dysregulation of pre-mRNA alternative splicing (AS) is closely associated with cancers.In this project, we we report that nuclear PTEN interacts with the splicing machinery, spliceosome, to regulate its assembly and pre-mRNA splicing.
Sample scope Single cell
Release date 2018-04-25
Submitter Shen  shao  ming  (smshen01@sibs.ac.cn)
Organization Shanghai Jiaotong Universit School of Medicine
Submission date 2018-04-25

Project Data

Resource name Description
BioSample (6) -
SAMC030008 pten knockout shRNA2 293T cell lines
SAMC030007 pten knockout shRNA1 293T cell lines
SAMC030006 wild-type 293T cell
SAMC030005 re-expression of PTENC124S
SAMC030004 re-expression of wild-type PTEN
SAMC030003 PTEN shRNA#1 293T cells
GSA (1) -
CRA000899 Nuclear PTEN safeguards pre-mRNA splicing to link Golgi extension and secretion for its tumor suppressive role
-