Accession PRJCA000779
Title MDR-TB
Relevance Medical
Data types Whole genome sequencing
Organisms Mycobacterium tuberculosis
Description Here we performed whole-genome sequencing of 357 MDR-TB strains in 4600 representative sputum samples from the First National Survey of Drug-resistant Tuberculosis (i.e., the Fourth National Epidemiological Survey of Tuberculosis, 2007-2008) in China covering 31 provinces and 70 counties. Drug-susceptibility testing was conducted using 17 antituberculosis drugs including all the first-line antituberculosis drugs (isoniazid, rifampicin, ethambutol, streptomycin, pyrazinamide) and 12 second-line antituberculosis drugs (para-aminosalicylic acid, kanamycin, ethionamide, amikacin, capreomycin, cycloserine, linezolid, clofazimine, moxifloxacin, ofloxacin, bedaquiline, delamanid), representing the most comprehensive drug-resistance profile so far. We identified 86 drug-resistance genes/IGRs/SNPs (58 new ones) using four methods (three statistical methods and one machine learning method). Interestingly, the analysis of the effective population size changes of Chinese MDR-TB strains reveals some issues during the social and economic transition period.
Sample scope Multiisolate
Release date 2019-04-01
Publication
PubMed ID Article title Journal name DOI Year
30321294 Cross-sectional Whole-genome Sequencing and Epidemiological Study of Multidrug-resistant Mycobacterium tuberculosis in China Clinical Infectious Diseases 10.1093/cid/ciy883 2019
36646991 The mutation rate of rpoB gene showed an upward trend with the increase of MIRU10, MIRU39 and QUB4156 repetitive number BMC Genomics 10.1186/s12864-023-09120-y 2023
Submitter Fei    Chen  (chenfei@big.ac.cn)
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2018-03-04

Project Data

Resource name Description
BioSample (424)  show -
GSA (1) -
CRA000786 MDR-TB