Accession PRJCA000779
Title MDR-TB
Relevance Medical
Data Types Whole genome sequencing
Organisms Mycobacterium tuberculosis
Description Here we performed whole-genome sequencing of 357 MDR-TB strains in 4600 representative sputum samples from the First National Survey of Drug-resistant Tuberculosis (i.e., the Fourth National Epidemiological Survey of Tuberculosis, 2007-2008) in China covering 31 provinces and 70 counties. Drug-susceptibility testing was conducted using 17 antituberculosis drugs including all the first-line antituberculosis drugs (isoniazid, rifampicin, ethambutol, streptomycin, pyrazinamide) and 12 second-line antituberculosis drugs (para-aminosalicylic acid, kanamycin, ethionamide, amikacin, capreomycin, cycloserine, linezolid, clofazimine, moxifloxacin, ofloxacin, bedaquiline, delamanid), representing the most comprehensive drug-resistance profile so far. We identified 86 drug-resistance genes/IGRs/SNPs (58 new ones) using four methods (three statistical methods and one machine learning method). Interestingly, the analysis of the effective population size changes of Chinese MDR-TB strains reveals some issues during the social and economic transition period.
Sample scope Multiisolate
Release date 2019-04-01
Submitter Fei    Chen  (
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2018-03-04

Project Data

Resource name Description
BioSample (424) -
SAMC026768 non-MDR_8246
SAMC026767 non-MDR_8137
SAMC026766 non-MDR_8105
SAMC026765 non-MDR_7103
SAMC026764 non-MDR_6102
SAMC026763 non-MDR_5148
SAMC026762 non-MDR_5103
SAMC026761 non-MDR_4207
SAMC026760 non-MDR_4110
SAMC026759 non-MDR_3326
SAMC026758 non-MDR_3207
SAMC026757 non-MDR_3140
SAMC026756 non-MDR_3101
SAMC026755 non-MDR_30139
SAMC026754 non-MDR_29102
SAMC026753 non-MDR_29101
SAMC026752 non-MDR_28117
SAMC026751 non-MDR_28107
SAMC026750 non-MDR_26108
SAMC026749 non-MDR_24244
SAMC026748 non-MDR_24107
SAMC026747 non-MDR_23555
SAMC026746 non-MDR_23515
SAMC026745 non-MDR_23334
SAMC026744 non-MDR_23333
SAMC026743 non-MDR_23204
SAMC026742 non-MDR_22110
SAMC026741 non-MDR_2146
SAMC026740 non-MDR_2109
SAMC026739 non-MDR_20116
SAMC026738 non-MDR_19316
SAMC026737 non-MDR_19310
SAMC026736 non-MDR_19210
SAMC026735 non-MDR_19204
SAMC026734 non-MDR_19108
SAMC026733 non-MDR_18412
SAMC026732 non-MDR_18409
SAMC026731 non-MDR_18304
SAMC026730 non-MDR_18303
SAMC026729 non-MDR_18238
SAMC026728 non-MDR_18207
SAMC026727 non-MDR_18134
SAMC026726 non-MDR_18129
SAMC026725 non-MDR_17314
SAMC026724 non-MDR_17202
SAMC026723 non-MDR_17120
SAMC026722 non-MDR_16546
SAMC026721 non-MDR_16406
SAMC026720 non-MDR_16404
SAMC026719 non-MDR_16212
SAMC026718 non-MDR_16205
SAMC026717 non-MDR_16102
SAMC026716 non-MDR_15201
SAMC026715 non-MDR_15173
SAMC026714 non-MDR_15104
SAMC026713 non-MDR_14338
SAMC026712 non-MDR_14301
SAMC026711 non-MDR_14205
SAMC026710 non-MDR_14122
SAMC026709 non-MDR_13231
SAMC026708 non-MDR_13204
SAMC026707 non-MDR_12263
SAMC026706 non-MDR_11204
SAMC026705 non-MDR_10308
SAMC026704 non-MDR_10307
SAMC026703 non-MDR_10210
SAMC026702 non-MDR_10141
SAMC026701 MDR_9160
SAMC026700 MDR_9156
SAMC026699 MDR_8247
SAMC026698 MDR_8232
SAMC026697 MDR_8214
SAMC026696 MDR_8213
SAMC026695 MDR_8211
SAMC026694 MDR_8150
SAMC026693 MDR_8134
SAMC026692 MDR_8128
SAMC026691 MDR_8127
SAMC026690 MDR_8124
SAMC026689 MDR_8119
SAMC026688 MDR_8112
SAMC026687 MDR_8111
SAMC026686 MDR_8104
SAMC026685 MDR_7171
SAMC026684 MDR_7153
SAMC026683 MDR_7133
SAMC026682 MDR_7131
SAMC026681 MDR_7119
SAMC026680 MDR_7118
SAMC026679 MDR_7114
SAMC026678 MDR_6165
SAMC026677 MDR_6157
SAMC026676 MDR_6145
SAMC026675 MDR_6135
SAMC026674 MDR_6133
SAMC026673 MDR_6132
SAMC026672 MDR_6128
SAMC026671 MDR_6113
SAMC026670 MDR_6109
SAMC026669 MDR_5169
SAMC026668 MDR_5168
SAMC026667 MDR_5166
SAMC026666 MDR_5163
SAMC026665 MDR_5162
SAMC026664 MDR_5160
SAMC026663 MDR_5158
SAMC026662 MDR_5152
SAMC026661 MDR_5149
SAMC026660 MDR_5136
SAMC026659 MDR_5134
SAMC026658 MDR_5132
SAMC026657 MDR_5131
SAMC026656 MDR_5128
SAMC026655 MDR_5116
SAMC026654 MDR_5114
SAMC026653 MDR_5112
SAMC026652 MDR_5110
SAMC026651 MDR_5107
SAMC026650 MDR_5106
SAMC026649 MDR_5105
SAMC026648 MDR_5102
SAMC026647 MDR_4256
SAMC026646 MDR_4255
SAMC026645 MDR_4253
SAMC026644 MDR_4249
SAMC026643 MDR_4224
SAMC026642 MDR_4205
SAMC026641 MDR_4204
SAMC026640 MDR_4203
SAMC026639 MDR_4202
SAMC026638 MDR_4164
SAMC026637 MDR_4160
SAMC026636 MDR_4152
SAMC026635 MDR_4149
SAMC026634 MDR_4148
SAMC026633 MDR_4147
SAMC026632 MDR_4146
SAMC026631 MDR_4145
SAMC026630 MDR_4142
SAMC026629 MDR_4129
SAMC026628 MDR_4128
SAMC026627 MDR_4117
SAMC026626 MDR_4113
SAMC026625 MDR_4112
SAMC026624 MDR_4107
SAMC026623 MDR_3364
SAMC026622 MDR_3355
SAMC026621 MDR_3352
SAMC026620 MDR_3349
SAMC026619 MDR_3338
SAMC026618 MDR_3320
SAMC026617 MDR_3319
SAMC026616 MDR_3311
SAMC026615 MDR_3306
SAMC026614 MDR_3305
SAMC026613 MDR_3293
SAMC026612 MDR_3292
SAMC026611 MDR_3284
SAMC026610 MDR_3283
SAMC026609 MDR_3271
SAMC026608 MDR_3240
SAMC026607 MDR_3224
SAMC026606 MDR_3220
SAMC026605 MDR_3209
SAMC026604 MDR_3208
SAMC026603 MDR_3202
SAMC026602 MDR_31251
SAMC026601 MDR_31213
SAMC026600 MDR_3118
SAMC026599 MDR_3112
SAMC026598 MDR_31104
SAMC026597 MDR_30167
SAMC026596 MDR_30166
SAMC026595 MDR_30165
SAMC026594 MDR_30161
SAMC026593 MDR_30159
SAMC026592 MDR_30157
SAMC026591 MDR_30155
SAMC026590 MDR_30152
SAMC026589 MDR_30147
SAMC026588 MDR_30126
SAMC026587 MDR_30124
SAMC026586 MDR_30119
SAMC026585 MDR_30118
SAMC026584 MDR_30111
SAMC026583 MDR_29175
SAMC026582 MDR_29171
SAMC026581 MDR_29131
SAMC026580 MDR_29127
SAMC026579 MDR_29120
SAMC026578 MDR_28174
SAMC026577 MDR_28158
SAMC026576 MDR_28144
SAMC026575 MDR_28133
SAMC026574 MDR_28103
SAMC026573 MDR_27164
SAMC026572 MDR_27154
SAMC026571 MDR_27149
SAMC026570 MDR_27126
SAMC026569 MDR_26124
SAMC026568 MDR_26101
SAMC026567 MDR_25142
SAMC026566 MDR_24272
SAMC026565 MDR_24267
SAMC026564 MDR_24187
SAMC026563 MDR_24136
SAMC026562 MDR_23562
SAMC026561 MDR_23560
SAMC026560 MDR_23557
SAMC026559 MDR_23408
SAMC026558 MDR_23402
SAMC026557 MDR_23356
SAMC026556 MDR_23344
SAMC026555 MDR_23342
SAMC026554 MDR_23341
SAMC026553 MDR_23338
SAMC026552 MDR_23324
SAMC026551 MDR_23264
SAMC026550 MDR_23258
SAMC026549 MDR_23234
SAMC026548 MDR_23215
SAMC026547 MDR_23120
SAMC026546 MDR_22268
SAMC026545 MDR_22257
SAMC026544 MDR_22243
SAMC026543 MDR_22242
SAMC026542 MDR_22230
SAMC026541 MDR_22226
SAMC026540 MDR_22222
SAMC026539 MDR_22216
SAMC026538 MDR_22204
SAMC026537 MDR_22160
SAMC026536 MDR_22149
SAMC026535 MDR_2189
SAMC026534 MDR_2167
SAMC026533 MDR_2166
SAMC026532 MDR_2115
SAMC026531 MDR_20217
SAMC026530 MDR_20165
SAMC026529 MDR_20163
SAMC026528 MDR_20161
SAMC026527 MDR_20137
SAMC026526 MDR_19466
SAMC026525 MDR_19441
SAMC026524 MDR_19420
SAMC026523 MDR_19368
SAMC026522 MDR_19361
SAMC026521 MDR_19359
SAMC026520 MDR_19357
SAMC026519 MDR_19342
SAMC026518 MDR_19340
SAMC026517 MDR_19329
SAMC026516 MDR_19261
SAMC026515 MDR_19216
SAMC026514 MDR_19213
SAMC026513 MDR_19209
SAMC026512 MDR_19128
SAMC026511 MDR_19107
SAMC026510 MDR_19102
SAMC026509 MDR_18568
SAMC026508 MDR_18566
SAMC026507 MDR_18559
SAMC026506 MDR_18558
SAMC026505 MDR_18428
SAMC026504 MDR_18410
SAMC026503 MDR_18408
SAMC026502 MDR_18350
SAMC026501 MDR_18253
SAMC026500 MDR_18252
SAMC026499 MDR_18236
SAMC026498 MDR_18225
SAMC026497 MDR_18221
SAMC026496 MDR_18218
SAMC026495 MDR_18214
SAMC026494 MDR_18212
SAMC026493 MDR_18206
SAMC026492 MDR_18201
SAMC026491 MDR_18163
SAMC026490 MDR_18154
SAMC026489 MDR_18144
SAMC026488 MDR_18135
SAMC026487 MDR_18128
SAMC026486 MDR_17366
SAMC026485 MDR_17244
SAMC026484 MDR_17238
SAMC026483 MDR_17227
SAMC026482 MDR_17213
SAMC026481 MDR_17174
SAMC026480 MDR_17171
SAMC026479 MDR_17166
SAMC026478 MDR_17146
SAMC026477 MDR_17111
SAMC026476 MDR_17106
SAMC026475 MDR_16556
SAMC026474 MDR_16543
SAMC026473 MDR_16537
SAMC026472 MDR_16527
SAMC026471 MDR_16517
SAMC026470 MDR_16514
SAMC026469 MDR_16513
SAMC026468 MDR_16510
SAMC026467 MDR_16467
SAMC026466 MDR_16466
SAMC026465 MDR_16430
SAMC026464 MDR_16424
SAMC026463 MDR_16412
SAMC026462 MDR_16401
SAMC026461 MDR_16360
SAMC026460 MDR_16359
SAMC026459 MDR_16351
SAMC026458 MDR_16242
SAMC026457 MDR_16207
SAMC026456 MDR_16163
SAMC026455 MDR_16155
SAMC026454 MDR_16151
SAMC026453 MDR_16142
SAMC026452 MDR_16136
SAMC026451 MDR_16109
SAMC026450 MDR_15462
SAMC026449 MDR_15448
SAMC026448 MDR_15447
SAMC026447 MDR_15429
SAMC026446 MDR_15414
SAMC026445 MDR_15403
SAMC026444 MDR_15401
SAMC026443 MDR_15353
SAMC026442 MDR_15334
SAMC026441 MDR_15327
SAMC026440 MDR_15319
SAMC026439 MDR_15312
SAMC026438 MDR_15301
SAMC026437 MDR_15228
SAMC026436 MDR_15142
SAMC026435 MDR_15130
SAMC026434 MDR_15129
SAMC026433 MDR_15127
SAMC026432 MDR_14368
SAMC026431 MDR_14361
SAMC026430 MDR_14349
SAMC026429 MDR_14348
SAMC026428 MDR_14347
SAMC026427 MDR_14332
SAMC026426 MDR_14327
SAMC026425 MDR_14315
SAMC026424 MDR_14314
SAMC026423 MDR_14306
SAMC026422 MDR_14305
SAMC026421 MDR_14268
SAMC026420 MDR_14265
SAMC026419 MDR_14263
SAMC026418 MDR_14257
SAMC026417 MDR_14245
SAMC026416 MDR_14236
SAMC026415 MDR_14226
SAMC026414 MDR_14220
SAMC026413 MDR_14165
SAMC026412 MDR_14112
SAMC026411 MDR_13263
SAMC026410 MDR_13242
SAMC026409 MDR_13232
SAMC026408 MDR_13206
SAMC026407 MDR_13168
SAMC026406 MDR_13167
SAMC026405 MDR_13165
SAMC026404 MDR_13162
SAMC026403 MDR_13157
SAMC026402 MDR_13137
SAMC026401 MDR_13130
SAMC026400 MDR_12467
SAMC026399 MDR_12448
SAMC026398 MDR_12428
SAMC026397 MDR_12423
SAMC026396 MDR_12418
SAMC026395 MDR_12366
SAMC026394 MDR_12359
SAMC026393 MDR_12340
SAMC026392 MDR_12332
SAMC026391 MDR_12314
SAMC026390 MDR_12270
SAMC026389 MDR_12259
SAMC026388 MDR_12257
SAMC026387 MDR_12251
SAMC026386 MDR_12240
SAMC026385 MDR_12179
SAMC026384 MDR_12178
SAMC026383 MDR_12177
SAMC026382 MDR_12174
SAMC026381 MDR_12153
SAMC026380 MDR_12128
SAMC026379 MDR_12103
SAMC026378 MDR_1161
SAMC026377 MDR_1135
SAMC026376 MDR_11280
SAMC026375 MDR_11278
SAMC026374 MDR_11277
SAMC026373 MDR_11269
SAMC026372 MDR_11263
SAMC026371 MDR_11244
SAMC026370 MDR_1124
SAMC026369 MDR_11239
SAMC026368 MDR_11220
SAMC026367 MDR_11171
SAMC026366 MDR_11168
SAMC026365 MDR_11166
SAMC026364 MDR_11151
SAMC026363 MDR_11125
SAMC026362 MDR_11110
SAMC026361 MDR_1106
SAMC026360 MDR_10459
SAMC026359 MDR_10456
SAMC026358 MDR_10454
SAMC026357 MDR_10452
SAMC026356 MDR_10448
SAMC026355 MDR_10443
SAMC026354 MDR_10431
SAMC026353 MDR_10410
SAMC026352 MDR_10328
SAMC026351 MDR_10309
SAMC026350 MDR_10216
SAMC026349 MDR_10181
SAMC026348 MDR_10142
SAMC026347 MDR_10138
SAMC026346 MDR_10133
SAMC026345 MDR_10107
GSA (1) -
CRA000786 MDR-TB