Accession PRJCA000678
Title Cooperation of Asxl1 and Nf1 alterations
Relevance Model organism
Data Types Transcriptome or Gene expression
Histone modification
Organisms Mus musculus
Description ASXL1 is frequently mutated in myeloid malignancies. While ASXL1 has been known to co-occur with other gene mutations, the molecular mechanisms underlying the leukemogenesis associated with ASXL1 and other cooperating gene mutations remain unclear. To Explore underlying the molecular mechanisms of cooperation, we performed RNA-seq and ChIP-seq against histone modifications for cKit+ cells from mice of four genotypes.
Sample scope pooled
Release date 2019-01-01
Publication
PubMed ID Article title Journal name DOI Year
30226831 Chromatin regulator Asxl1 loss and Nf1 halpoinsufficiency cooperate to accelerate myeloid malignancy The Journal of Clinical Investigation 10.1172/JCI121366 2018
Data provider
Data provider Data provider URL
Feng-Chun Yang http://bm.med.miami.edu/faculty/facultybmb/feng-chun-yang-md-phd
Biomaterial provider Feng-Chun Yang
Grants
Agency program Grant ID Grant title
National Institutes of Health CA172408 NA
National Institutes of Health CA185751 NA
National Institutes of Health HL112294 NA
National Natural Science Foundation of China (NSFC) 91731302 NA
National Natural Science Foundation of China (NSFC) 81470340 NA
National Natural Science Foundation of China (NSFC) 81570113 NA
Social Development Project of Jiangsu Province CXTDA2017014 NA
Chinese Academy of Sciences (CAS) 2015079 NA
Tianjin Municipal Science and Technology Commission 16JCZDJC34500 NA
Submitter Fuhong    He  (hefh@big.ac.cn)
Organization Beijing Institute of Genomics, Chinese Academy of Sciences
Submission date 2017-10-28

Project Data

Resource name Description
BioSample (45) -
SAMC045493 DKO_AN277_K4me3
SAMC045492 DKO_AN275_K4me3
SAMC045491 DKO_AN274_K4me3
SAMC045490 DKO_AN274_Input
SAMC045489 DKO_Nf177_K4me3
SAMC045488 DKO_Nf175_K4me3
SAMC045487 DKO_Nf177_Input
SAMC045486 DKO_A1009_K4me3
SAMC045485 DKO_A1007_K4me3
SAMC045484 DKO_A1006_K4me3
SAMC045483 DKO_A1007_Input
SAMC045482 DKO_WT171_K4me3
SAMC045481 DKO_WT003_K4me3
SAMC045480 DKO_WT002_K4me3
SAMC045479 DKO_WT002_Input
SAMC045478 8m_Nhet263_K4me3
SAMC045477 8m_Nhet263_Input
SAMC045476 8m_Nhet032_K4me3
SAMC045475 8m_Nhet030_Input
SAMC045474 8m_Ahet265_K4me3
SAMC045473 8m_Ahet265_Input
SAMC045472 8m_Ahet022_K4me3
SAMC045471 8m_Ahet020_Input
SAMC019654 8m_AsNf_199
SAMC019653 8m_AsNf_191
SAMC019652 8m_AsNf_000
SAMC019651 8m_WT_214
SAMC019650 8m_WT_182
SAMC019649 8m_WT_000
SAMC019648 6wk_AsNf_12
SAMC019647 6wk_AsNf_09
SAMC019646 6wk_Nf1_04
SAMC019645 6wk_Nf1_03
SAMC019644 6wk_Asxl1_17
SAMC019643 6wk_Asxl1_16
SAMC019642 6wk_WT_18
SAMC019641 6wk_WT_13
SAMC019640 8m_AsNf_160
SAMC019639 8m_AsNf_152
SAMC019638 8m_Nf1_227
SAMC019637 8m_Nf1_194
SAMC019636 8m_Asxl1_196
SAMC019635 8m_Asxl1_183
SAMC019634 8m_WT_184
SAMC019633 8m_WT_170
GSA (2) -
CRA000668 ChIP-seq data for cKit+ cells from Asxl1/Nf1 mutant mice
CRA000666 RNA-seq data for cKit+ cells from mice aged 8 months
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