| Accession |
PRJCA000678 |
| Title |
Cooperation of Asxl1 and Nf1 alterations |
| Relevance |
Model organism |
| Data types |
Transcriptome or Gene expression
Histone modification
|
| Organisms |
Mus musculus
|
| Description |
ASXL1 is frequently mutated in myeloid malignancies. While ASXL1 has been known to co-occur with other gene mutations, the molecular mechanisms underlying the leukemogenesis associated with ASXL1 and other cooperating gene mutations remain unclear. To Explore underlying the molecular mechanisms of cooperation, we performed RNA-seq and ChIP-seq against histone modifications for cKit+ cells from mice of four genotypes. |
| Sample scope |
pooled |
| Release date |
2019-01-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 30226831
|
Chromatin regulator Asxl1 loss and Nf1 halpoinsufficiency cooperate to accelerate myeloid malignancy
|
The Journal of Clinical Investigation
|
10.1172/JCI121366
|
2018
|
|
|
| Data provider |
|
| Biomaterial provider |
Feng-Chun Yang |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Institutes of Health
|
|
CA172408
|
NA
|
| National Institutes of Health
|
|
CA185751
|
NA
|
| National Institutes of Health
|
|
HL112294
|
NA
|
| National Natural Science Foundation of China (NSFC)
|
|
91731302
|
NA
|
| National Natural Science Foundation of China (NSFC)
|
|
81470340
|
NA
|
| National Natural Science Foundation of China (NSFC)
|
|
81570113
|
NA
|
| Social Development Project of Jiangsu Province
|
|
CXTDA2017014
|
NA
|
| Chinese Academy of Sciences (CAS)
|
|
2015079
|
NA
|
| Tianjin Municipal Science and Technology Commission
|
|
16JCZDJC34500
|
NA
|
|
|
| Submitter |
Fuhong
He (hefh@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission date |
2017-10-28 |
