Accession PRJCA000524
Title Human brain evolution
Relevance Evolution
Umbrella project

eGPS: evolutionary Genotype-Phenotype Systems biology

Cranial Capacity & Structure

Genetic mechanism and function of key genes in the evolution of animal brain

Data types Phenotype or Genotype
Transcriptome or Gene expression
Raw sequence reads
Organisms Macaca mulatta
Description We report the application of RNA sequencing technology for high-throughput profiling of RNA expression in monkey tissues. By obtaining over four billion bases of sequence of brain, liver and muscle from MCPH1 transgenic monkey and two control monkeys. We find that brain tissue showed more differentially expressed genes compared with those in liver and muscle. Finally, we show that This result implies that the over expressed huMCPH1 may have a global impact on multiple organs of the transgenic monkey, and it has the largest impact on the brain in terms of gene numbers.
Sample scope RNA
Release date 2020-07-10
Grants
Agency program Grant ID Grant title
Chinese Academy of Sciences (CAS) Strategic Priority Research Program of Chinese Academy of Sciences (CAS) XDB13000000
Submitter Lei    Shi  (leshi@med.umich.edu)
Organization Kunming Institute of Zoology(KIZ)
Submission date 2017-08-17

Project Data

Resource name Description
BioSample (63)  show -
GSA (1) -
CRA000343 MCPH1_monkey_transcriptome